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白细胞介素27抗肿瘤作用的研究进展 被引量:2

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摘要 白细胞介素27(IL-27)是IL-6/IL-12家族的一种异源二聚体细胞因子。IL-27能够通过促进CD4^+T细胞向Th1细胞分化,抑制Th2细胞、Th17细胞分化,增强细胞毒性T细胞效应,发挥抗肿瘤作用。IL-27能够调节抗血管生成相关蛋白和趋化因子的表达,从而抑制肿瘤相关血管的生成。此外,IL-27还能通过抑制上皮-间质转化等过程从多个方面参与抗肿瘤作用。因此,IL-27作为抗肿瘤细胞因子已受到越来越多的关注,成为肿瘤免疫治疗中的热点,本文总结了IL-27在抗肿瘤以及抗转移方面的研究进展。
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2016年第6期837-839,844,共4页 Chinese Journal of Cellular and Molecular Immunology
基金 "重大新药创制"科技重大专项(2012ZX09103-301-022)
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参考文献33

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二级参考文献48

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