丙泊酚杂质E与J的合成

Synthesis of Impurity E and J of Propofol

以丙泊酚为原料，经过三氯化铁氧化、硼氢化钠还原两步反应得到了丙泊酚杂质E,收率73．5％。丙泊酚杂质J是由丙泊酚经氧化剂硝酸铈铵氧化得到，收率78-3％。目标化合物的结构经MS和。HNMR确证。该合成方法简单，原料易得，操作简单，收率较高。

Propofol impurity E was synthesized via oxidation and reduction using propofol as raw material while impurity J was obtained by oxidizing of propofol in the presence of ammonium cerium nitrate; yields were 73.5% and 78.3%, respectively. These two compounds were confirmed by 1H NMR and MS spectra. This synthetic method was simple with easy-obtaining raw materials and high reaction yield.