摘要
观察口服尼可地尔对急性ST段抬高型心肌梗死患者左心功能的影响。选取80例急性ST段抬高型心肌梗死并行PCI术的患者,随机分为对照组和尼可地尔组。两组患者均于PCI术后1周、8周行心脏彩超检查,并于入院即刻、PCI术后8周抽取静脉血测定脑钠肽(BNP)。结果显示:与对照组比较,尼可地尔组的LVEDD、LVESD、WMSI明显降低、LVEF明显升高(P<0.01),且尼可地尔组的血清BNP水平明显降低(P<0.01)。提示口服尼可地尔可改善急性ST段抬高型心肌梗死患者的左心功能。
This article is to discuss the influence of Nicorandil on left heart function in patients with acute myocardial infarction after PCI. The authors selected 80 patients with STEMI and they were randomly divided into control group （n= 40） and nicorandil group （n=40）. At 1 week and 8 weeks after PCI, we recorded left ventricular end diastolic diameter （LVEDD）, left ventrieular end systolic diameter （LVESD） and count left ventricular ejection fraction （LVEF）, wall motion score index （WMSI） by echoeardiography in order to estimate left ventricular function. The level of BNP in blood was detected in admission and 2 month after. Compared to control group, the results show that the LVEDD, LVESD, WMSI were lower and the LVEF was higher in nicorandil group, there was statistical significance （P〈0.01）. At the same time, the level of serum BNP was lower in nicorandil group （P〈0.01）. Oral nieorandil can improve the left heart function of the patients with AMI.
出处
《医学与哲学（B）》
2016年第4期20-22,25,共4页
Medicine & Philosophy(B)
关键词
尼可地尔
急性心肌梗死
心功能
脑钠肽
nicorandil, acute myocardial infarction, heart function, brain natriuretic peptide （BNP）
