摘要
目的：探讨山东济宁地区PD-1基因多态性与乙型肝炎病毒感染的关系。方法：收集2014年1月-2015年12月邹城市人民医院就诊的319例乙型肝炎病毒感染者为实验组，502例健康体检者作为对照组。通过PCR-RFLP的方法对PD-1＊1进行基因分型，分析年龄，性别以及等位基因频率和基因型的分布情况。结果：HBV感染组PD-1＊1位点AA的等位基因频率高于非HBV感染人群11.1个百分点；不同年龄组HBV感染比例存在明显差异，50岁以上人群更易感染乙肝，差异具有统计学意义（P〈0.05）。结论：山东济宁地区人群中HBV易感性与PD-1基因多态性有显著相关性，HBV感染与年龄密切相关。
Objective：To investigate the relationship between PD-1 gene polymorphism and hepatitis B virus infection in the Jining district of Shandong.Methods：From January 2014 to December 2015, 319 Cases of hepatitis B virus infection in Zoucheng People’s hospital were collected as the experimental group, and 502 healthy persons were selected as the control group. Gene typing was performed by PCR-RFLP to analyze the distribution of age, sex, allele frequency and genotype in PD-1.Results： Infection group was higher than that in non HBV infection group in the frequency of AA genotype （P〈0.05）. The people more than 50 years old is probably get HBV infection, and the difference is statistically significant （P〈0.05）.Conclusions： There was a significant correlation between the susceptibility of HBV and PD-1 gene polymorphism in the Jining district of Shandong population, HBV Infection is correlated with age.
出处
《医学检验与临床》
2016年第2期1-3,共3页
Medical Laboratory Science and Clinics
基金
山东省科技发展计划（2012GSF11908）.
