我院不同院区2011年主要目标菌耐药性检测与分析

Main target bacteria detection and analysis of hospital compound in our hospital in 2011

目的：探讨在统一管理和检验模式下，同一所医院的3个院区主要目标菌耐药性特点是否有所不同。方法：采用SPSS19.0统计数据包，应用行＆#215;列表资料检验统计3个院区2011年主要目标菌的耐药性特点。结果：3个院区主要目标菌的耐药性有所不同：大肠埃希菌阿米卡星、环丙沙星、庆大霉素、妥布霉素、呋喃妥因、哌拉西林/他唑巴坦3个院区比较有显著性差异（P〈0.05）；肺炎克雷伯菌阿米卡星、环丙沙星、头孢吡肟、妥布霉素、呋喃妥因、哌拉西林/他唑巴坦3个院区比较有显著性差异（P〈0.05）；鲍曼不动杆菌3个院区所有检测抗菌药物比较均有显著性差异（P〈0.05）；铜绿假单胞菌氨苄西林/舒巴坦、美罗培南、头孢他啶、妥布霉素、亚胺培南、左氧氟沙星、哌拉西林/他唑巴坦3个院区比较有显著性差异（P〈0.05）；金黄色葡萄球菌苯唑西林、环丙沙星、庆大霉素、利福平、左氧氟沙星3个院区比较有显著性差异（P〈0.05）。结论：在统一管理和检验模式下，同一医院不同院区其主要目标菌耐药性的发生有其本身的特点，这与新老院区在应用抗菌药物特点方面、医院感染控制方面有一定关联。

Objective：To investigate the antibiotic resistance characteristic of target bacterias in three different area of a hospital by the unified testing methods. The results will help our hospital to improve the level of rational use of antibiotics.Methods：Chi square test was used to investigate the antibiotic resistance characteristic of target bacterias in three different area of a hospital.Results：The antibiotic resistance characteristic of target bacterias was different. The characteristic of E. coli was significant different in three areas for Amikacin, Ciprofloxacin, Gentamicin, Tobramycin, Nitrofurantoin, and Piperacillin/Tazobactam （P〈0.05） The characteristic of klebsiella pneumonia was significant different for Amikacin, Ciprofloxacin, Cefepime, Tobramycin, Nitrofurantoin, and Piperacillin/Tazobactam （P〈0.05）. The characteristic of Acinetobacter baumannii was significant different for all testing antibiotics（P〈0.05）. The characteristic of pseudomonas aeruginosa was significant different for Ampicillin/ Sulbactam, Meropenem, Ceftazidime, Tobramycin, Imipenem, Levofloxacin, Piperacillin/ Tazobactam （P〈0.05）, and staphylococcus aureus was significant different for Oxacillin, Ciprofloxacin, Gentamicin, Rifampicin, Levofloxacin （P〈0.05）.Conclusions：Because of the difference of antibiotics application and hospital infection control in different area of a hospital,we found that the antibiotic resistance characteristic of target bacteria was different.