幽门螺杆菌感染对胃外疾病的影响

Influence of Helicobacter pylori infection on extragastric diseases

幽门螺杆菌(Helicobacter pylori,H.pylori)在胃内定植及其相关致病作用的发现是现代胃肠病学一个重要的里程碑.近30年的研究表明,许多上消化道疾病,如慢性胃炎、消化性溃疡、胃癌和胃黏膜相关淋巴组织淋巴瘤的自然史都与这种细菌的存在有关.此外,H.pylori常参与一些胃外疾病致病过程,特别是那些以持续性、低度系统性炎症为特征的疾病.其可能机制为低等级炎症状态的诱导和分子模拟机制等.本文就H.pylori感染与胃外疾病,如自身免疫性疾病、肿瘤性疾病、心血管疾病及其他相关疾病之间的关系,及可能的机制作一简单综述.

The discovery of Helicobacter pylori（H.pylori）colonization of the stomach and its pathogenic effects is a crucial landmark in modern gastroenterology.There have been many studies reporting that the natural history of manydisorders of the upper gastrointestinal tract,such as chronic gastritis,peptic ulcer disease,gastric cancer and MALT lymphoma are linked with the presence of this bacterium.Moreover,H.pylori is often involved in the pathogenic processes of a variety of extra-gastric diseases,especially those characterized by persistent and low grade systemic inflammation.The proposed mechanisms ranging from the induction of a low grade inflammatory state to the occurrence of molecular mimicry mechanisms.This paper will review the results of the most important studies on the association of H.pylori infection with extra-gastric diseases,such as autoimmune,neoplastic,cardiovascular and other related disorders,as well as possible mechanisms implicated in the pathogenesis of these extragastric diseases.