摘要
Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α- glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the AgO） complexes （9-16） inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver（1） （9） was the most potent （ICso = 3.21 nmol/L）. Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and thev are discussed in this report.
Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α- glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the AgO） complexes （9-16） inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver（1） （9） was the most potent （ICso = 3.21 nmol/L）. Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and thev are discussed in this report.
