120例非淋球菌性尿道炎患者支原体和衣原体感染及药敏状况

120 cases of non gonococcal urethritis mycoplasma and chlamydia infection and drug resistance status

目的探讨非淋球菌性尿道炎的支原体和衣原体感染及药敏状况。方法于2014年6—12月对宁波市北仑区第二人民医院120例非淋球菌性尿道炎患者进行沙眼衣原体、解脲支原体（Uu）及人型支原体培养，并对支原体进行药敏试验，比较男性、女性患者支原体、衣原体检测结果，观察解脲支原体和人型支原体的阳性药敏试验结果。结果在检测阳性的120例患者中Uu所占比例最高，达41．67％（50／120）；其次是Mh，占31．67％（38／120）。其中Uu在女性中的检出率（57．14％）明显高于男性（28．13％），差异有统计学意义（x2=10．35，P〈0．05）。支原体对原始霉素的敏感率最高，解脲支原体和人型支原体的敏感率均达到100．00％；其次是强力霉素，解脲支原体的敏感率达到98．00％，人型支原体的敏感率达到100．00％；解脲支原体和人型支原体对交沙霉素的敏感率分别为96．00％和90．48％；解脲支原体和人型支原体对四环素的敏感率分别为92．00％和90．48％。结论支原体感染主要以Uu为主，临床支原体感染治疗可以根据药敏试验结果合理选择抗生素，原始霉素、强力霉素的敏感性较高。

Objective To investigate non gonococcal urethritis mycoplasma and chlamydia infection and drug sensitivity status. Methods From June 2014 to December 2014,120 cases of non gonococcal urethritis patients in our hospital were given chlamydia trachomatis,ureaplasma, mycoplasma detection and mycoplasma culture and drug sensi- tivity test of mycoplasma. Mycoplasma and chtamydia test results were compared between male and female patients. Positive drug sensitivity test results of ureaplasma urealyticum （Uu） and mycoplasma hominis （Mh） were observed. Results Among the 120 patients with positive detection, the proportion of Uu was the highest, up to 41.67% （50/120） ;the second was Mh,accounting for 31.67% （38/120）. The detection rate of Uu in women （57.14%） was significantly higher than that in males （28.13%）, and the difference was statistically significant （X2 = 10.35, P 〈 0.05 ）. The susceptibility of mycoplasma to pristinamycin susceptible rate highest, Uu and type mycoplasma reached 100.00% ;followed by doxycycline, the susceptibility of Uu reached 98.00% and the susceptibility of Mh to 100.00% ;sensitive rates of Uu and Mh to josamycin were 96.00% and 90.48%. The sensitive rates of Uu and Mh to tetracycline were 92.00% and 90.48% respectively. Conclusion The mycoplasma infection was mainly caused by Uu. Clinical treatment of mycoplasma infection can be based on the drug sensitivity test results to reasonably choose antibiotics, and sensitive rates of pristinamycin, doxycycline were higher.