高尿酸血症与良性前列腺增生的相关性研究

Correlation between Hyperuricemia and Benign Prostatic Hyperplasia

目的：探讨高尿酸血症（ HUA）与良性前列腺增生（ BPH）的相关性。方法：选择2014年1月～3月在我院体检中心体检的60岁以上的老年男性共502例，测量血压、腰围，现场询问病史和进行国际前列腺症状评分（ IPSS），检测空腹血尿酸、TG、TC、LDL－C、HDL－C、空腹血糖等，超声测量及计算前列腺体积。按血尿酸是否＞420μmol／L将受检者分为HUA 组和血尿酸正常组（ NUA）。比较2组的代谢指标及前列腺相关指标的差异，并采用logistic回归模型分析HUA与各临床指标的相关性。结果：HUA与腹型肥胖、高TG血症、代谢综合征（CDS2007）、BPH及下尿路症状评级（LUTS）有明显的相关性（P＜0．05）。结论：高尿酸血症与良性前列腺增生具有明显的相关性，其可能是良性前列腺增生的危险因素之一。

Objective：To evaluate the correlation between hyperuricemia （ HUA） and benign prostatic hyperplasia（ BPH） .Methods：A total of 502 elderly male patients, who carried out health checkup during January,2014 and March,2014 in our health management cen-ter, were included in this study.All the following indexes were collected：blood pressure, waistline, medical history, international prosta-tic symptom score （IPSS）, serum uric acid （UA）, triglycerides （TG）, total cholesterol （TC）, low -density lipoprotein cholesterol （ LDL-C） , high-density lipoprotein cholesterol （ HDL-C） , fasting blood glucose （ FBG） , and prostate volume （ PV） measured by ul-trasound.Patients with higher level of UA more than 420μmol/L were included into the HUA group while the other patients with normal UA （ NUA） were in the NUA group.Both the metabolic and prostate related indexes in the two groups were compared, and the correlation between HUA and each index were analyzed using logistic regression model.Results：HUA was signifi cantly associated with abdominal o-besity, hypertriglyceridemia, metabolic syndrome （ CDS2007）, BPH and lower urinary tract symptoms （ LUTS） rating.Conclusion：HUA should be closely related with BPH,which may be a risk factor .