生长分化因子-15(GDF-15)表达水平与心肌梗死致心衰程度的相关性研究

Correlation between the Expression Level of Growth Differentiation Factor-15(GDF-15) and the Degree of Heart Failure Induced by Myocardial Infarction

目的:探讨生长分化因子-15(GDF-15)表达水平与心肌梗死致心衰程度的相关性。方法:选取70例心肌梗死致心衰患者为研究对象并将其归入研究组(A组),将同一时间段入院体检的70例健康志愿者纳入对照组(B组)中。两组患者均给予静脉血检测,记录其血清中生长分化因子-15(GDF-15)表达水平,对比分析心衰程度同GDF-15间的相关性。结果:A组患者心功能Ⅰ级者13例(18.5%),心衰I度者24例(34.3%),心衰Ⅱ度者27例(38.6%),心衰Ⅲ度者6例(8.6%);A组患者血清GDF-15表达水平均明显高于B组患者(P<0.05);A组中,患者血清GDF-15表达水平随着心衰程度的增加而上升(P<0.05),两者呈正相关性。结论:血清中GDF-15水平检测可作为判断心肌梗死致心衰患者心衰程度的重要指标,值得临床推广。

Objective： To investigate the relationship between the expression of growth differentiation factor -15 （GDF-15） and the degree of heart failure induced by myocardial infarction. Methods： 70 patients with heart failure induced by myocardial infarction were selected as study subjects and enrolled in the study group （group A）. 70 healthy volunteers were enrolled in the control group （group B）. Patients in the two groups were given venous blood test. The serum growth differentiation factor -15 （GDF-15） were recorded. The correlation between the degree of heart failure and GDF-15 were analyzed. Results： Patients in group A with cardiac function grade Ⅰ were 13 cases （18.5%）. Patients with Ⅰ degree of heart failure were 24 cases（34.3%）. Patients with Ⅱ degree of heart failure were 27 cases （38.6%）. Patients with Ⅲ degree of heart failure were 6 cases （8.6%）. The with serum GDF-15 levels in the group A were significantly higher than that of control group （P〈0.05）, the level of serum GDF-15 expression increased with the degree of heart failure increased （P〈0.05）. Conclusion： The level of GDF-15 can be used as an important indicator to determine the degree of heart failure in patients with myocardial infarction, which is worthy of clinical application.