不同剂量右美托咪定对老年患者术后认知功能影响的研究

Study on the Effect of Different Doses Dexmedetomidine on Postoperative Cognitive Function for Elderly Patients

目的分析右美托咪定对于老年全麻手术患者认知功能的影响。方法选取我院择期肠癌手术治疗的72例老年患者,依据右美托咪定剂量均分为实验组(包括DD、DM、DX 3个亚组)和NS组,观察手术前后MMSE评分变化和不良事件发生情况。结果术后实验组MMSE评分优于NS组,DD、DM组不良事件发生率高于DX和NS组,P<0.05;但是DX和NS间不良事件对比,差异无统计学意义(P>0.05)。结论右美托咪定有利于改善术后认知功能,但是高剂量右美托咪定能够增加不良反应的发生风险。

Objective Analysis the effect of dexmedetomidine on cognitive function of elderly patients with general anesthesia.Methods Selected 72 cases of elderly patients with colorectal cancer in our hospital. According to the dexmedetomidine dose during the surgery, they were divided into two groups, the experimental group （including DD, DM, DX 3 subgroups） and NS group. The changes in MMSE score and adverse events were observed before and after the surgery.ResultsAfter surgery, the MMSE score of the experimental group was better than the NS group. In group DD and DM, the incidence of adverse events was higher than DX and NS groups,P〈0.05, but there was no signiifcant difference in adverse events between DX and NS （P〉0.05）.ConclusionDexmedetomidine can improve cognitive function after surgery, but high doses of dexmedetomidine can increase the risk of adverse reaction.