缬沙坦联合贝那普利治疗糖尿病肾病的临床观察

Clinical Observation on Valsartan Combined With Benazepril in Treatment of Diabetic Nephropathy

目的：探讨在糖尿病肾病的治疗中，应用缬沙坦联合贝那普利的临床疗效。方法选取我院2014年10月～2015年10月收治疗的糖尿病肾病患者150例，随机均分为3组，在常规降糖、降压治疗的基础上，对照Ⅰ组单纯口服贝那普利，对照Ⅱ组单纯口服缬沙坦，观察组采用缬沙坦联合贝那普利治疗。结果对照Ⅰ组和对照Ⅱ组治疗的总有效率分别为77.0%和79.0%，差异无统计学意义（P＞0.05），且均低于观察组的96.0%，P＜0.05。结论与单一用药方法相比，应用缬沙坦联合贝那普利对糖尿病肾病进行治疗，可控制患者血压、血糖稳定，使尿蛋白降低，缓解临床症状，无严重不良反应，疗效显著。

Objective To investigate the treatment of diabetic nephropathy, the application of the clinical efficacy of valsartan combined with benazepril. Methods From October 2014 to October 2015, 150 patients with diabetic nephropathy patients in our hostpial, which were randomly divided into three groups, on the basis of conventional antidiabetic, antihypertensive therapy, the control groupⅠsimple oral shellifsh enalapril, control groupⅡvalsartan alone, the observation group valsartan combined with benazepril treatment. Results In control group and the control groupⅡ,Ⅰ treatment of the total effective rate of 77.0% and 79.0% respectively, no significant difference （P〉0.05） between the two groups, and were lower than in the observation group 96.0%,P〈0.05. Conclusion Compared with single drug method, valsartan combined with benazepril on diabetic treatment, can control blood pressure, blood sugar stable, reduce urinary protein, relieve symptoms, no serious adverse reactions, a signiifcant effect.