胃癌血清标志物的临床意义及研究进展

Clinical significance and reseach advance of serum markers of gastric cancer

胃癌在我国的发病率非常高,其特点在于恶性程度高、患者的预后差,大多数患者确诊时已达到中晚期,治疗的效果差。因此,早期的诊断和治疗是降低胃癌病死率、延长患者生命时间的关键所在。但是早期胃癌缺乏特异性的临床症状和体征,难以与胃良性疾病区分开来。目前,临床中胃癌诊断方法主要通过病理和胃镜检查,会对患者造成一定的损伤,不利于胃癌早期筛查工作的开展。血清肿瘤标志物检测是临床中无痛、无损、简单、快捷的方式,作为一种无创检查方式在多种肿瘤的诊断中得到应用,受到医疗工作者的重视。本文主要探讨癌胚抗原、血清胃蛋白酶原、胃泌素-17等在胃癌诊断中的价值。

Gastric cancer is a common malignant tumor,which is characterized by high incidence,high malignancy and poor prognosis of the patients,most of patients have reached the middle and advanced period when confirmed,with poor curative effect.Therefore,the early diagnosis and treatment are the key to reduce the mortality rate of gastric cancer and prolong the life time.But early gastric cancer is lack of specific clinical symptoms and signs,and it is difficult to distinguish benign gastric diseases.At present,the main methods in clinic diagnosis of gastric cancer are by pathology and endoscopy,which will be in a certain damage to patients and is not conducive to carry out screening of early gastric cancer.The serum tumor marker in clinical detection is a painless,non-destructive,simple and quick way,as a noninvasive method it has been used in the diagnosis of tumors and payed attention to by medical researchers.This paper mainly discusses the value of carcinoembryonie antigen,serum pepsinogen and gastrin-17 in diagnosing gastric cancer.