腹腔镜辅助卵巢打孔术治疗多囊卵巢综合征合并不孕的临床效果

Clinical effect of laparoscopic assisted ovarian drilling in the treatment of polycystic ovary syndrome combined with infertility

目的探讨腹腔镜辅助卵巢打孔术治疗多囊卵巢综合征合并不孕的临床效果。方法选取本院2012年8月-2014年6月收治的106例多囊卵巢综合征合并不孕患者作为研究对象,随机分为对照组和治疗组,各53例。对照组采取达英-35治疗,观察组采用腹腔镜辅助卵巢打孔术治疗。比较两组治疗前后的性激素水平变化情况,并随访1年,观察两组的妊娠情况。结果观察组均顺利完成腹腔镜辅助卵巢打孔术,无中转腹。两组治疗后的T及LH水平显著低于治疗前,差异有统计学意义（P〈0.05）。观察组治疗后的T及LH水平显著低于对照组治疗后,差异有统计学意义（P〈0.05）。随访1年,观察组的妊娠率为90.57%,其中足月38例,流产7例,早产3例。对照组妊娠率为28.30%,其中足月6例,流产8例,早产1例。观察组的妊娠率显著高于对照组,差异有统计学意义（P〈0.05）。结论腹腔镜辅助卵巢打孔术治疗多囊卵巢综合征合并不孕的临床效果优于药物治疗,可显著降低T及LH水平,其对卵巢储备能力的影响小,术后妊娠率高,妊娠结局良好,可作为该病的理想治疗方法之一。

Objective To explore the clinical effect of laparoscopic assisted ovarian drilling in the treatment of polycystic ovary syndrome combined with infertility. Methods 106 polycystic ovary syndrome combined with infertility patients from August 2012 to June 2014 in our hospital were selected and randomly divided into the control group and the observation group,53 cases in each group.The control group was given diane-35,the observation group was given laparo- scopic assisted ovarian drilling.The change condition of sex hormone level in the two groups before and after treatment was compared.By following up for 1 year,the pregnancy condition in the two groups was observed. Results Patients in the observation group completed laparoscopic assisted ovarian drilling smoothly and no transfer belly.The level of T and LH after treatment in the two groups was lower than that before treatment,with significant difference （P〈0.05）.The level of T and LH after treatment in the observation group was lower than that in the control group,with significant difference （P〈0.O5）.Followed up for 1 year,the pregnancy rate in the observation group was 90.57%,38 cases were mature,7 cases of abortion and 3 cases of preterm birth.The pregnancy rate in the control group was 928.30%,6 cases were mature,8 cases of abortion and 1 cases of preterm birth.The pregnancy rate in the observation group was higher than that in the control group,with significant difference （P〈0.05）. Conclusion The clinical effect of laparoscopic assisted ovarian drilling in the treatment of polycystic ovary syndrome combined with infertility is better than that of drug treatment, which can decrease the level of T and LH obviously,has less impact on ovarian reserve capacity and high postoperative pregnancy rate,better pregnancy outcome,it is one of an ideal treatment for this disease.