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左炔诺孕酮宫内节育系统和安宫黄体酮在围绝经期异常子宫出血治疗中的疗效观察 被引量:16

Curative effect observation of levonorgestrel intrauterine system and medroxyprogesterone acetate in the treatment of abnormal uterine bleeding in the perimenopausal period
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摘要 目的探讨左炔诺孕酮宫内节育系统和安宫黄体酮治疗围绝经期异常子宫出血的疗效。方法选取2013年1月-2015年1月本院收治的115例围绝经期异常子宫出血患者作为研究对象,根据治疗措施的不同分为对照组(55例)和观察组(60例)。对照组给予戊酸雌二醇和安宫黄体酮,观察组给予左炔诺孕酮宫内节育系统和安宫黄体酮治疗。比较两组治疗前后的子宫内膜厚度、月经量、血红蛋白水平以及流血控制时间、止血完全时间、临床疗效。结果两组治疗后的子宫内膜厚度小于治疗前,月经量少与治疗前,血红蛋白水平高于治疗前,差异有统计学意义(P〈0.05)。观察组治疗后的子宫内膜厚度小于对照组,月经量少与对照组,血红蛋白水平高于对照组,差异有统计学意义(P〈0.05)。观察组的流血控制时间、止血完全时间短于对照组,差异有统计学意义(P〈0.05)。观察组的总有效率为98.3%,显著高于对照组的85.5%,差异有统计学意义(P〈0.05)。结论左炔诺孕酮宫内节育系统和安宫黄体酮治疗围绝经期异常子宫出血效果显著,值得临床推广应用。 Objective To explore the curative effect of levonorgestrel intrauterine system and medroxyprogesterone acetate in the treatment of abnormal uterine bleeding in the perimenopausal period. Methods 115 cases of abnormal uterine bleeding in the perimenopausal period from January 2013 to January 2015 in our hospital were selected and divided into the control group (55 cases) and the detection group (60 cases) according to different treatment methods.The control group was treated with estradiol valerate and medroxyprogesterone acetate,the observation group was treated with levonorgestrel intrauterine system and medroxyprogesterone acetate.The endometrial thickness,menstrual blood volume,the level of hemoglobin and the control bleeding time,bleeding completely time,the clinical curative effect in the two groups was compared. Results The endometrial thickness after treatment in the two groups was less than that before treatment,menstrual blood volume after treatment in the two groups was less than that before treatment,the level of hemoglobin in the two groups was higher than that before treatment,with significant difference (P〈0.05).The endometrial thickness after treatment in the observation group was less than that in the control group after treatment,menstrual blood volume after treatment in the observation group was less than that in the control group after treatment,the level of hemoglobin after treatment in the observation group was higher than that in the control group after treatment,with sig- nificant difference (P〈0.05).The control bleeding time,bleeding completely time in the observation group was shorter than that in the control group,with significant difference (P〈0.05).The total effective rate in the observation group was 98.3%,which was higher than 85.5% in the control group,with significant difference (P〈0.05). Conclusion The effect of levonorgestrel intrauterine system and medroxyprogesterone acetate in the treatment of abnormal uterine bleeding in the perimenopausal period is slgnificant,it is worthy of clinical promotion and application.
作者 韩金秀
出处 《中国当代医药》 2016年第14期60-62,共3页 China Modern Medicine
关键词 左炔诺孕酮宫内节育系统 安宫黄体酮 围绝经期 异常子宫出血 Levonorgestrel intrauterine system Medroxyprogesterone acetate Perimenopausal period Abnormal uterine bleeding
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