氟化羟基磷灰石的制备及氟的影响研究

Preparation of Fluoride-hydroxyapatite and Study on Effects of Fluoride

以Ca(CH_3COO)_2·H_2O、KH_2PO_4和KF·2H_2O为原料,室温下采用化学沉淀法在p H为7的条件下制备得到氟化羟基磷灰石(FHA)。通过对不同氟含量的FHA进行XRD、FTIR等手段分析,结果表明加入F不会改变FHA晶体结构,但晶格参数a减小;F取代HA中的OH,随着F加入量增大,F取代OH难度增加;在FHA中形成氢键OH…F,约束晶胞规则有序生长,使FHA的结晶性提高;HA中原有的长程有序排列…HOHOHO…逐渐转变为F和OH的间隔性排列…F(HO)_nF…;FHA晶体形态为短棒状,长度约为150 nm,直径约为20 nm,随F含量增加,FHA晶粒直径增大。

Fluoride-hydroxyapatite was synthesized by chemical precipitation method using Ca（CH3COO）2·H2O、KH2PO4andKF·2H2O as raw materials, controlling the p H value to 7. The structure and morphology of FHA containing different fluoride contents were analyzed by XRD, FTIR, etc.. Results showed that F wouldn’t change the crystal structure of FHA but the lattice parameter a was decreased. OH was replaced by F, and OH was replaced difficultly with fluoride content increasing. OH…F bond was formed between crystalline, and the bond restrained the ordered growth of fluoride-hydroxyapatite crystal cells, which resulted in that the crystallinity increased as F content increased. The initial long-range order…HOHOHO…was transferred to intermittent arrangement of F and OH, …F（HO）nF…. The morphology of fluoride-hydroxyapatite was rod-like shape with the length of about 150 nm, diameter of about 20 nm, and the width increased along with the increase of F content.