183例前列腺癌的临床分析

A clinical study of 183 patients with prostate cancer

目的 :为了了解前列腺癌临床流行病学的变迁情况。方法 :对我院自 1970年 9月至 1999年 1月近 30年间收治的 183例前列腺癌患者以 1991年为界分成二组进行回顾性分析。结果 :(1)后期前列腺癌患者明显增多 ,是前期的 1 5 1倍 ;其平均年龄 (70岁 )较前期 (6 6 4岁 )明显升高 (P <0 0 5 ) ,年龄构成亦更趋老年化 ;(2 )后期由于血清PSA的应用 ,早期前列腺癌患者所占比例较前期明显升高 (30 9%比 2 2 % ,P <0 0 5 ) ,而中晚期患者所占比例则有所下降 (78%和 6 9 1% ,P <0 0 5 )。但不可否认的是新发病例仍以中晚期特别是D期居多 (5 2 7% )。 (3)治疗以双侧睾丸切除为基础加激素治疗和 /或放疗的治疗方案最为常见 ,亦比较符合国情。结论 :血清PSA可提高早期前列腺癌的诊断率 ;

Objective:To evaluate the trends of clinic epidemiology of prostate cancer in 30 years.Methods:183 patients with prostate cancer treated during 1970 1999 were divided into two groups: before 1991 as early period and after 1991 as late period. Results:1.The number of patients during the late period was 1.51 fold that during the early period. The average age during the late period was older than that during the early period. 2.Because of serum PSA examination, the ratio of the patients on early stages (A or B) during the late period was higher than that during the early period. 3.Bilateral orchiectomy was the most frequent method in the treatments of prostate cancer.Conclusion:It may be possible to increase the early detection of prostate cancer by serum PSA examination. Bilateral orchiectomy was the most frequent endocrine therapy.