肾上腺皮质癌的诊断和治疗

Diagnosis and management of adrenocortical carcinoma

目的 :提高肾上腺皮质癌的诊治水平。方法 :回顾分析 12例肾上腺皮质癌的临床诊治资料。结果 :功能性肿瘤 8例 ,主要以柯兴综合征为主 ,性征异常者及原发性醛固酮增多症相对少见。无功能性肿瘤 4例。影像学检查显示肿瘤大小 5 5～ 18 5cm ,平均 7 5cm。CT和MRI提示肿瘤边界不规则 ,内部质地不均匀。 12例均行肾上腺癌根治性手术 ,3年生存率2 5 %。结论 :影像学检查结合临床表现可以对肾上腺皮质癌作出诊断。

Objective:To evaluate the diagnosis and treatment of adrenocortical carcinoma.Methods:12 cases of adrenocortical carcinoma were reviewed.Results:8 patients had functional tumors, which suffered from Cushing's syndrome. 4 patients had nonfunctional tumors. The diameter of the tumors ranged from 5 5 to 18 5 cm with a mean of 7 5 cm. On CT or/and MRI scan, the boundary of the tumor was not clear cut and the tumor density was usually uneven. Radical adrenolectomy was undertaken in 12 with a 3 year survival rate of 25%.Conclusion:Imaging procedures are important for the diagnosis of adrenocortical carcinoma. Radical resection is the effective treatment for adrenocortical carcinoma.