喜炎平联合利巴韦林治疗小儿手足口病疗效的Meta分析

Meta-analysis of Xiyanping Combined with Ribavirin in Treatment of Children with Hand-foot-mouth Disease

目的:评价喜炎平联合利巴韦林治疗小儿手足口病的临床疗效。方法:计算机检索Pubmed,Embase,Cochrane library,中国生物医学文摘数据库(CBM),中国期刊全文数据库(CNKI),维普数据库(VIP)和万方数据库中,关于喜炎平联合利巴韦林治疗小儿手足口病的随机对照试验(randomized clinical trials,RCT),纳入研究的质量评价和资料提取由2名研究者独立严格进行,采用RevMan 5.3软件进行Meta分析。结果:最终纳入62个RCT,共8 945例患儿。Meta分析结果显示,喜炎平联合利巴韦林治疗小儿手足口病在总有效率、体温恢复正常时间、疱疹消退时间、手足皮疹消退时间、口腔溃疡愈合时间、治愈时间和住院时间等方面与对照组比较均有统计学意义(P<0.05)。结论:喜炎平联合利巴韦林治疗小儿手足口病具有一定的疗效。但现有研究质量偏低,需要更多设计严谨的高质量、多中心的随机双盲临床研究进一步验证。

Objective： To evaluate the clinical efficacy of Xiyanping combined with ribavirin in the treatment of children with hand-foot-mouth disease. Method： Pubmed, Embase, Cochrane library, CNKI,CBM,Wan Fang Data and VIP were searched for randomized clinical trials（ RCT） on Xiyanping combined with ribavirin in the treatment of children with hand-foot-mouth disease. Two independent reviewers strictly evaluated the quality of the included studies and extracted the data,then Meta-analysis was done by using Rev Man 5. 3 software.Result： Eventually 62 RCT involving a total of 8 945 children were included in the study. Meta-analysis results showed that there was statistically significant difference in total effective rate,antifebrile time,herpes fading time,recovery time of erythra in hands and feet, healing time of oral ulcer, cure time and hospital stay between Xiyanping combined with ribavirin group and control group in the treatment of children with hand-foot-mouth disease（ P〈0. 05）. Conclusion： Xiyanping combined with ribavirin had certain effect in the treatment of children with hand-foot-mouth disease,but the quality of existing studies is poor,so more rigorous high quality multi-center randomized double-blind clinical studies are required for verification.