三七通舒胶囊治疗急性脑梗死合并消化道溃疡的疗效观察

Effect of Sanqi tongshu capsule on acute cerebral infarction with history of peptic ulcer

目的评价三七通舒胶囊对存在消化道溃疡病史的急性脑梗死患者的临床疗效和安全性。方法既往存在消化道溃疡病史的73例脑梗死患者随机分为两组,对照组为常规治疗或其他治疗方案,实验组在常规治疗基础上加三七通舒胶囊。治疗30 d后,观察两组治疗前后欧洲卒中评分(Europe Stroke Score,ESS)、巴塞尔指数评分(Barthel Index,BI)及消化道不良反应。结果治疗前两组患者的ESS评分和BI评分均数无显著差异(P>0.05),治疗后实验组患者的ESS评分和BI评分均高于治疗前,且高于对照组(P<0.05)。两组患者治疗后血小板聚集率、血清血栓素B2(TXB2)以及白介素-6(IL-6)的水平均有减低,但二者之间比较存在明显差异(P<0.05)。两组消化道出血的发生率未见明显差异(P>0.05)。结论三七通舒胶囊可通过抑制血小板聚集、减轻炎性反应治疗有消化道溃疡病史的急性脑梗死疗效确切。且不增加消化道出血风险。

Objective Assessed efficacy and safety of sanqi shutong capsule treating acute cerebral infarct patients with history of peptic ulcer. Methods 73 patients with acute cerebral infarct were assigned to two groups randomly,among whom 35 received sanqi shutong capsule added to the routine therapy for one month and 38 received the routine therapy.Observed the Europe Stroke Score（ ESS）,Barthel Index（ BI） of cerebral infarct before and after treatment. The serum levels of TXB2 and IL-6 and platelet aggregation were detected at different stages of treatment（ day 0,day 3,day 7 and day30）. Results The Europe Stroke Score（ ESS）,Barthel Index（ BI） of the treatment group were increased significantly and were higher than those of the control group（ P〈0. 05）. From the 3rd day,the level of TXB2 and IL-6 was decreased significantly in the treatment group（ P〈0. 05）. From the 7th day,platelet aggregation was decreased significantly in the treatment group too（ P〈0. 05）. Moreover,two groups had no differences in incidence of gastrointestinal bleeding. Conclusions Sanqi shutong capsule had efficacy of curing and had mild digestive tract symptoms for cute cerebral infarct patients with history of peptic ulcer.