吡拉西坦治疗脑梗死患者早期认知功能障碍的疗效观察

Therapeutic Effect of Laci Staw on Early Cognitive Impairment in Patients with Cerebral Infarction

目的探讨吡拉西坦注射液在有早期认知功能障碍的脑梗死患者中的治疗效果。方法选取重庆医科大学附属第一医院及附属大学城医院120例有认知功能障碍的脑梗死患者为临床研究对象(2012年1月至2015年10月间),将全部患者随机分为对照组和研究组(n=60)。对照组给予基础治疗,研究组在基础治疗上应用吡拉西坦注射液治疗,观察两组认知功能损害和疗效。结果治疗前研究组和对照组的MMSE评分差异无统计学意义。治疗后研究组的MMSE评分明显高于对照组,且两组间的数据比较有统计学差异(P<0.05)。研究组总有效率明显高于对照组(P<0.05)。结论临床中有认知功能障碍的脑梗死患者在基础治疗上应用吡拉西坦注射液治疗能够改善认知功能,并且提高临床疗效。

Objective To investigate the therapeutic effect of piracetam and sodium chlorid injection in treatment of post-stroke cognitive impairment patients.Methods From January 2012 to October 2015,120 cases of post-stroke cognitive impairment patients were recruited and divided into study group and control group,each had 60 cases.The control group patients received basic treatment,the study group patients applied piracetam and sodium chlorid injection treatment on the basic treatment,cognitive impairment and therapeutic effect were be observed.Result There were no significant differences between the two groups in MMSE scores before treatment.MMSE scores of the two groups were higher after treatment separately,the significant differences were observed between the two groups in MMSE scores after treatment（P〈0.05）.There were significant differences between the two groups when compared the total effective rate（P〈0.05）.Conclusion The application of piracetam and sodium chlorid injection in treatment of post-stroke cognitive impairment patients can improve cognitive function,and get better therapeutic effect.