摘要
目的研究脆性组氨酸三联体(FHIT)和Ki67在宫颈癌中的表达及其意义。方法采用免疫组织化学SP法检测子宫颈癌(68例)和正常宫颈组织(37例)中FHIT和Ki67的表达。结果正常宫颈组织和宫颈癌中FHIT表达率(86.49%vs 46.15%)比较有显著统计学意义(P<0.05);宫颈癌组织中FHIT蛋白的表达与宫颈癌组织的病理和临床分期有关,Ki67表达的阳性率正相反,而宫颈癌中FHIT蛋白的表达与Ki67呈负相(r=-1.395)。结论 FHIT和Ki67在宫颈癌的发生、发展有关作用,其在早期检测宫颈癌具有一定的参考价值。
Objective To study the expression and significance of fragile histidine triplet （FHIT） and Ki67 in cervical cancer. Methods Cervical cancer （68 cases） and normal cervical tissue （37 cases） by Using immunohistochemical SP method detected the expression of FHIT and Ki67. Results FHIT expression in normal cervical tissues and cervical cancer rates （86.49% vs 46.15%） was a significant statistical significance （P〈0.05）; FHIT protein expression in cervical cancer tissue associated with the pathology and clinical staging of cervical cancer tissue; Ki67 expression of positive predictive value was on the contrary, while the expression of FHIT protein in cervical cancer and Ki67 showed negative phase（r=-1.395）. Conclusion FHIT and Ki67 expression is associated with the occurrence and development of cervical cancer, and in the early detection of cervical cancer has certain reference value.
出处
《中国医药指南》
2016年第15期31-31,33,共2页
Guide of China Medicine
