幽门螺杆菌相关蛋白在脑梗死患者血清中的表达

The expression of Helicobacter pylori cytotoxin-associated gene A protein in the serum of patients with atherosclerotic cerebral infarction

目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)细胞毒素相关蛋白A(CagA)在动脉粥样硬化性脑梗死患者血清中的表达。方法对脑梗死组65例患者的中性粒细胞、血纤维蛋白原、hsCRP及CagA-Hp-IgG抗体进行测定,采用超声检测颈部血管,所有检测结果与健康对照组进行比较。结果研究组与对照组血清CagA-Hp抗体阳性率分别为60%和32%;H.pylori抗体阳性组较阴性组相比,血hs-CRP和纤维蛋白原升高明显(t=4.872,P<0.05;t=1.982,P<0.05);H.pylori抗体阳性者狭窄及颈动脉斑块发生率分别为53.8%和89.7%,与对照组的26.9%和53.8%相比差异具有统计学意义(χ2=5.826和6.297,P均<0.05)。结论动脉粥样硬化性脑梗死患者的H.pylori感染率高于健康人,H.pylori感染可能与脑梗死的发生有关。

Objective To study the expression of Helicobacter pylori（H.pylori）cytotoxin-associated gene A protein（CagA）in the serum of patients with atherosclerotic cerebral infarction.Methods Neutrophil counts,fibrinogen and hs-CRP levels,and CagA-Hp-IgG antibodies were measured in 65 patients with cerebral infarction.The carotid arteries were examined using ultrasound.All results of the cerebral infarction group were compared with those of a healthy control group.Results The positive rates of CagA-HP antibody in the serum of the experimental group and the control group were 60% and 32%,respectively.The blood levels of hs-CRP and fibrinogen in the H.pylori antibody-positive group were significantly higher than those in the H.pylori antibody-negative group（t=4.872,P〈0.05;t=1.982,P〈0.05）.The incidence rates of stenosis and carotid plaque in H.pylori antibody-positive patients were 53.8% and 89.7%,respectively,and the differences were significant compared with the incidence rates of 26.9% and 53.8%in the control group（χ^2=5.826 and 6.297,both P〈0.05）,respectively.Conclusion The prevalence of H.pylori infection is higher in patients with atherosclerotic cerebral infarction than in healthy population.Therefore,H.pylori infection might be associated with the occurrence of cerebral infarction.