摘要
以三聚氯氰、正己胺、牛磺酸、2-氨基苯并咪唑为原料合成了一种新型苯并咪唑衍生物。通过红外光谱、核磁共振氢谱、高分辨率质谱对产物进行了结构表征,采用吊片法研究产物的表面活性,考察并比较了产物和2-氨基苯并咪唑的抑菌性能。结果表明:产物的临界胶束浓度及相应的表面张力分别为8.5×10-3 mol/L和33.1mN/m。产物对大肠杆菌和金黄色葡萄球菌的生长均具有较好的抑制作用,其中对金黄色葡萄球菌的抑制更显著;与2-氨基苯并咪唑相比,表面活性的引入使产物的抑菌性能大大提高。所合成的新型苯并咪唑衍生物兼备表面活性、抑菌的优良性能。
A novel benzimidazole derivative was synthesized from cyanuric chloride,n-hexyl amine,taurine and 2-aminobenzimidazole.Its chemical structure was confirmed by IR,^1H NMR and MS.Surface activity of the product was studied by hanging plate method,and its antibacterial activity was evaluated and compared with 2-aminobenzimidazole.The critical micelle concentration（cmc）was 8.5×10^-3 mol/L and the corresponding surface tension（γ（cmc））was 33.1mN/m,respectively.The results indicated that the product exhibited good antibacterial activity against Escherichia coli（E.coli）and Staphylococcus aureus（S.aureus）and was more significant against S.aureus.And compared with 2-aminobenzimidazole,the antibacterial activity of the product improved greatly owing to the introduction of surface activity.The novel benzimidazole derivative exhibited excellent performance of surface activity and antibacterial activity.
出处
《精细石油化工》
CAS
CSCD
北大核心
2016年第3期70-73,共4页
Speciality Petrochemicals
关键词
苯并咪唑衍生物
合成
表面活性
抑菌性
benzimidazole derivative
synthesis
surface activity
antibacterial activity
