NB-UVB多疗程治疗白癜风的疗效比较

Efficacy of different courses of NB-UVB phototherapy on the treatment of vitiligo

观察NB-UVB进行多疗程治疗白癜风时各疗程疗效之间的比较。筛选符合本研究要求完成3个疗程光疗的50例白癜风患者,每个疗程的治疗包括：至少30次光疗;暂停光疗休息3-6个月。记录同一块白斑在各疗程完成后的复色情况。同一块白斑,第1个疗程和第2个疗程疗效差异无统计学意义,第1个疗程疗效优于第3个疗程疗效（P〈0.05）,第2个疗程疗效优于第3个疗程疗效（P〈0.05）;3个疗程平均单次照射剂量比较差异无统计学意义。NB-UVB治疗白癜风时,前2个疗程疗效相同,但第3个疗程疗效降低;进入平台期后休息3个月白斑恢复到初始治疗时的光敏感。

To evaluate the efficacy of different courses of Narrowband Ultraviolet B phototherapy（ NB-UVB） in the treatment of vitiligo. 50 vitiligo patients who had finished 3 courses of phototherapy and met the inclusion criteria were included in our study. Each course contained at least 30 times of phototherapy,and between two courses,there was a rest of 3 - 6 months. The repigmentation of each vitiligo lesion after every course of phototherapy was recorded. To the same lesion,the efficacy difference between the first course and the second course was not statistically significant. But the efficacy of the first course was better than the third course（ P 〈0. 05）,while the efficacy of the second course was also better than the third course（ P 〈0. 05）. There was no significant difference among the three courses concerning the average single irradiation dose. In conclusion,when using NB-UVB in treating vitiligo,the efficacy of first course was equivalent to the second course,but it reduced in the third course. Whenever a plateform stage occurs,a rest of more than 3 months is long enough for the vitiligo lesion to recover initial light sensitivity.