PFTK1在人非小细胞肺癌中的表达及临床意义

Clinical significance of PFTK1 expression in human non-small cell lung cancer

目的:研究PFTAIRE蛋白激酶1(PFTK1)在人类非小细胞肺癌(NSCLC)组织中的表达及其与NSCLC临床病理特征之间的关系,揭示PFTK1的表达在NSCLC中的临床意义。方法:采用免疫组织化学方法检测119例NSCLC组织中PFTK1的表达情况,并用X^2检验比较样本率,Kaplan-Meier法计算生存率,Log-Rank检验进行生存率的比较。结果:PFTK1在NSCLC组织中呈胞核和胞浆阳性。与癌旁组织比较,在119例NSCLC组织中,有76例肺癌组织PFTK1表达水平升高,占63.9%(76/119)。PFTK1的表达在NSCLC不同T分期间以及是否存在淋巴结转移组间的差异均具有统计学意义(P均<0.05),与年龄、性别、临床分期、病理分级、病理类型、肿瘤大小以及区域淋巴结N分期无明显相关性(P>0.05)。在肺鳞癌患者中控制分层因素N分期后进行生存分析显示PFTK1的表达水平越高,患者生存时间越短(P<0.05)。结论:PFTK1在人NSCLC中表达水平升高,并且PFTK1的表达与NSCLC的T分期及淋巴结转移具有相关性,影响NSCLC患者预后。PFTK1有望成为NSCLC潜在的生物学标志。

OBJECTIVE：To investigate the expression of PFTAIRE protein kinase 1（PFTK1） in human nonsmall cell lung cancer（NSCLC） and to analyze its clinical significance.METHODS：Immunohistochemistry was used to detect the protein expression of PFTK1 in 119 cases of NSCLC.The sample rate was tested by chi-square test.KaplanMetier method was used to calculate survival rates and survival rates were tested by Log-Rank test.RESULTS：In NSCLC tissues,PFTK1 existed mainly in the cytoplasm and nucleus.In the 119 cases,PFTK1 expression was higher in cancer than in adjacent normal alveolar epithelium tissues,and the ratio was 63.9%（76/119）.PFTK1 expression was significantly correlated with both different T（primary tumor） stage and lymph node metastasis（P〈0.05）,whereas it was not correlated with age,sex,clinical stage,pathological grade,pathology type,tumor size and N（regional lymph node）stage（P〉0.05）.In patients with lung squamous cell carcinoma,if stratification factor N stage was controlled,the survival analysis showed that when the expression level of PFTK1 was higher the overall survival time of patients was shorter（P〈0.05）.CONCLUSION：PFTK1 was overexpressed in NSCLC,was closely associated with T stage and lymph node metastasis,and affected prognosis of patients.PFTK1 may become a potential biomarker for NSCLC.