抗轮状病毒鸡卵黄免疫球蛋白治疗小儿轮状病毒肠炎临床观察

Clinical Observation of Anti-Rotavirus Egg Yolk Immunoglobulin in Treatment of Infantile Rotavirus Enteritis

目的:探讨抗轮状病毒鸡卵黄免疫球蛋白治疗小儿轮状病毒肠炎的临床效果。方法:选取小儿轮状病毒肠炎患儿130例,采用随机抽样方法分为对照组和观察组各65例,两组患儿入院后均给予常规对症治疗,对照组患儿加用双歧杆菌乳杆菌三联活菌治疗,观察组患儿加用抗轮状病毒鸡卵黄免疫球蛋白治疗,比较两组患儿临床疗效、平均病程、治疗后不同时间点腹泻次数、SIg A水平及轮状病毒含量等。结果:观察组患儿临床总有效率为95.38%,显著高于对照组的78.46%,差异有统计学意义(P<0.01);对照组患儿病程为(5.67±1.22)d,长于观察组的(4.50±1.09)d,差异有统计学意义(P<0.01);两组患儿治疗后不同时间点腹泻次数、SIg A水平及轮状病毒含量组内比较差异有统计学意义(P<0.05),其中对照组患儿治疗后3 d轮状病毒含量显著高于其他时间点,差异有统计学意义(P<0.05);观察组患儿治疗3 d、5 d、7 d及10 d后腹泻次数和轮状病毒含量均显著少于对照组,差异有统计学意义(P<0.05);观察组患儿治疗1 d、3 d、5 d、7 d及10 d后SIg A水平均显著高于对照组,差异有统计学意义(P<0.05)。结论:抗轮状病毒鸡卵黄免疫球蛋白治疗小儿轮状病毒肠炎,有助于促进病毒清除及SIg A形成,可有效改善临床症状体征,缩短病程。

Objective： To investigate clinical effects of anti-rotavirus egg yolk immunoglobulin in treatment of infantile rotavirus enteritis. Methods： One hundred and thirty children with infantile rotavirus enteritis were chosen and randomly divided into both group including control group（ 65 children） and experiment group（ 65 children）. The control group was given live combined bifidobacterium and lactobacillus,the experiment group was given anti-rotavirus egg yolk immunoglobulin on the basis of conventional symptomatic treatment. The clinical efficacy,average disease course,the number of diarrhea at different time points after treatment,levels of SIg A and the content of rotavirus of both groups were compared. Results： The clinical efficacy of experiment group was significantly higher than control group（ P0. 01）. The average disease course of experiment group was significantly shorter than control group（ P0. 01）.There were significant differences in number of diarrhea at different time points after treatment,levels of SIg A and the content of rotavirus in two groups（ P0. 05）,and the content of rotavirus of control group in 3 days after treatment was significant higher than other time points（ P0. 05）. The number of diarrhea and the content of rotavirus in 3 d,5 d,7 d and 10 d after treatment of experiment group were significantly less than control group（ P0. 05）. The levels of SIg A in 1 d,3 d,5 d,7 d and 10 d after treatment of experiment group were significantly higher than control group（ P 0. 05）. Conclusion： Compared with live combined bifidobacterium and lactobacillus,anti-rotavirus egg yolk immunoglobulin in treatment of infantile rotavirus enteritis is helpful to promote the virus clearance and SIg A formation,can efficiently improve the clinical symptoms and signs,shorten disease course.