难治性支原体肺炎与普通支原体肺炎患儿早期D-二聚体和C反应蛋白的比较及临床意义

Comparison and clinical significance of C-reactive protein and D-dimer of children with mycoplasma pneumoniae pneumonia and refractory Mycoplasma pneumonia

目的通过回顾性研究,比较普通型肺炎支原体肺炎(Mycoplasma Pneumoniae Pneumonia MPP)患儿及难治性肺炎支原体肺炎(refractory Mycoplasma pneumonia RMPP)患儿早期D-二聚体和C反应蛋白(Creactive protein,CRP),观察RMPP患儿与普通MPP患儿,在早期D-二聚体和CRP的差别,以协助对RMPP患儿临床的早期认识。方法回顾性收集肺炎支原体肺炎患儿115例,根据其病情及治疗的过程分为普通型MPP组63例和RMPP组52例,并设正常对照组60例。比较3组儿童中血清CRP和D-二聚体的数值。结果RMPP组患儿的D-二聚体和CRP均较正常对照组明显升高,差异有统计学意义(P<0.01);RMPP组患儿与普通型MPP组相比,D-二聚体明显升高,差异有统计学意义(P<0.01),但两组CRP差异无统计学意义。结论 D-二聚体检测对RMPP患儿早期诊断有一定的指导意义。

Objective To compare the difference between D-dimer and C-reactive protein in children with mycoplasma pneumoniae pneumonia in children with refractory mycoplasma pneumoniae pneumonia, and explore their clinical significance. Methods 115 children with MMP were divided into the common type mycoplasma pneumoniae pneumonia group （ n = 63 ） and the refractory mycoplasma pneumoniae pneumonia group （ n = 52）, and another 60 healthy children were selected as the control group. Their serum CRP and D-dimer were compared among the three groups. Results The RMMP group had significantly higher CRP and D-dimer levels than the other two groups did （ P 〈 0. 01 ）, but the difference of CRP between the two groups was not significant. Conclusion The detection of D-dimer in RMPP children has a certain significance for early diagnosis.