舒血宁对AECOPD患者内皮功能和凝血纤溶系统的影响

Effect of Shuxuening on endothelial function and coagulation and fibrinolysis systems in patients with AECOPD

目的探究舒血宁对AECOPD患者内皮功能和凝血纤溶系统的影响。方法收集于我院接受治疗的AECOPD患者120例为研究对象,随机分组;常规组患者60例,用常规方法进行治疗,舒血宁组患者60例,在常规组的基础上配合舒血宁进行治疗;之后对各组患者的各项指标[TM(血清血栓调节蛋白)、v WF(血管假血友病因子)、D-D(D-二聚体)、以及凝血四项指标)]进行比较。结果治疗结束后,舒血宁组的各项指标(TM、v WF以及D-D水平)的改善程度均显著好于常规组,差异有统计学意义(P<0.05);治疗结束后舒血宁组的FBG改善程度显著好于常规组,差异有统计学意义(P<0.05);TT、PT、APTT水平量组比较均没有显著差异,差异无统计学意义;治疗结束后舒血宁组总有效率为96.67%,常规组总有效率为56.67%,具有显著差异,有统计学的意义(P<0.05)。结论在常规治疗的同时配合舒血宁,能够对AECOPD患者内皮功能和凝血纤溶系统起到明显改善效果,治疗总有效率较高值得推广。

Objective To explore the influence of Shuxuening on endothelial function and coagulation and fibrinolysis systems in patients with AECOPD. Methods 120 AECOPD patients were randomly divided into the study group （60 cases） and the control group （60 cases）. All patients were given conventional treatment, and the study group was additionally given Shuxuening. Their TM, vWF, D - dimer, and coagulation indexes were compared. Results After treatment, the improvement of TM, vWF, D - dimer and coagulation indexes was more pronounced in the study group than in the control group （ P 〈 0. 05 ）. After treatment, FBG was significantly better in the study group than in the control group （P 〈0. 05）. The level of TT, PT and AFFF showed no significant difference between the two groups （ P 〉 0.05 ）. The total effective rate after was 96.67% in the study group and 56.67% in the control group （P 〈 0. 05 ）. Conclusion On the basis of conventional treatment, Shuxuening can improve endothelial function and coagulation and fibrinolysis systems in the treatment of AECOPD.