噻托溴铵治疗尘肺伴慢性阻塞性肺疾病对肺功能和血气指标的影响

Pulmonary function and blood gas index effect of thiamethoxam Joe bromide choline drug treatment on pneumoconiosis with COPD

目的观察噻托溴铵治疗尘肺伴慢性阻塞性肺疾病对肺功能和血气指标的影响。方法选取2014年6月——2015年5月沈阳军区总医院呼吸与重症医学科收治的尘肺伴慢性阻塞性肺疾病患者74例,按照随机数字表法分为观察组和对照组,每组37例。对照组采用常规治疗,观察组在此基础上联合噻托溴铵进行治疗。比较2组患者治疗后的临床疗效,治疗前后的肺功能、血气指标、生命体征变化及不良反应。结果治疗后,观察组患者总有效率为91.89%(34/37),高于对照组的72.97%(27/37)(P<0.05);肺活量、潮气量、每分钟通气量、最大通气量显著高于对照组[(1.9±0.3)L、(702.2±92.4)ml、(14.1±0.5)L、(49.4±0.7)L vs.(1.5±0.3)L、(614.3±60.3)ml、(12.6±0.4)L、(40.4±0.6)L],差异均具有统计学意义(P<0.05);pH、动脉血氧分压、动脉血氧饱和度水平明显高于对照组[(7.86±0.53)、(93.21±8.32)mmHg、(78.25±8.36)%vs.(7.46±0.42)、(72.42±6.86)mmHg、(64.05±7.33)%,P<0.05],动脉血二氧化碳分压明显低于对照组(40.26±8.32)mmHg vs.(57.32±2.53)mmHg,P<0.05];平均动脉压、心率、呼吸频率低于对照组[(86.31±4.24)mmHg、(87.35±10.22)次/min、(20.32±3.02)次/min vs.(91.04±5.22)mmHg、(97.67±12.41)次/min、(28.55±3.87)次/min,P<0.05]。2组不良反应发生率比较差异无统计学意义(8.11%vs.5.41%,P>0.05)。结论噻托溴铵应用于尘肺伴慢性阻塞性肺疾病患者,能明显改善患者的肺功能、血气指标,临床疗效良好。

Objective To study the pulmonary function and blood gas index effect of thiamethoxam Joe bromide choline drug on pneumoconiosis with COPD.Methods Seventy-four pneumoconiosis with COPD patients from June 2014 to May2015 in respiratory and critical care medicine,General Hospital of Shenyang Military were enrolled,according to the random indicator method,they was divided into observation group and control group,37 cases in each group.The control group using conventional treatment,the observation group also added thiamethoxam bromide.The efficiency of two groups was compared after treatment.They were compared with pulmonary function,blood gas index,vital signs change before and after the treatment,after treatment,determination of the two groups patients with clinical efficacy and adverse reactions were compared.Results After treatment,observation group of patients＇ total clinical efficacy rate was 91.89%（34/37）,which was significantly higher than the control group 72.97%（27/37）（P〈0.05）.Observation group of patients＇ lung capacity,tidal volume,minute ventilation,the chase volume were significantly higher than the control group[（1.9±0.3）L,（702.2±92.4）ml,（14.1±0.5）ml,（49.4±0.7）L vs.（1.5±0.3）L,（614.3±60.3）ml,（12.6±0.4）ml,（40.4±0.6）L],with statistically significant difference（P〈0.05）.The observation group of patients with pH,arterial blood oxygen partial pressure and spO_2 levels were significantly higher than the control group（7.86 ± 0.53）,（93.21 ±8.32）mmHg,（78.25±8.36）%vs.（7.46±0.42）,（72.42±6.86）mmHg,（64.05±7.33）%]（P〈0.05）,the arterial blood CO_2 partial pressure（40.26±8.32）mmHg significantly lower than the control group（57.32 ±2.53）mmHg（P〈0.05）.Observation group of patients with mean arterial pressure,heart rate,breathing rate was obviously lower than the control group[（86.31 ±4.24）mmHg,（87.35± 10.22） times/min,（20.32±3.02） times/min（91.04 ±5.22） mmHg,（97.67 ± 12.41） times/min,（28.55 ±3.87） times/min]（P〈0.05）.Conclusion It demonstrated that the choline thiamethoxam bromide used in patients with COPD and pneumoconiosis could obviously improve the patients blood gas index,pulmonary function,vital signs,clinical curative effect is good.