芬太尼透皮贴剂治疗126例癌痛临床观察

Clinical Study on Transdermal Fentanyl Used in Relieving Cancer Pain in 126 Cases

目的:观察芬太尼透皮贴剂治疗癌痛的疗效、不良反应。方法:对126例癌痛患者分为中度疼痛组和重度疼痛组,均用芬太尼贴剂进行止痛治疗,观察疗效、不良反应、生活质量评分变化,进行记录归纳。结果:126例癌痛均有不同程度的缓解,其中中度疼痛组的CR率为57.0%,重度疼痛组的CR率为54.5%,差异具有统计学意义。不良反应有头晕、便秘、恶心、嗜睡、皮肤瘙痒等,未出现严重不良反应。结论:芬太尼透皮贴剂在临床应用中,使用方便、效果明显、不良反应小。

Objective：To observe the clinical effect and adverse reaction of transdermal fentanyl in treating cancer pain. Methods：126 patients with cancer pain were divided into moderate and severe cancer pain group with the treatment of transdermal fentanyl, and the sum up the pain relief effects, adverse reactions, quality of life grading in patients received treatment. Results： Pain of those patients had relived at some degrees. For moderate group, CR is 57.0%;for severe group, CR is 54.5%. The difference is statistical significant.There was no severe averse events occurred such as dizziness, constipation, nausea, drowsiness and cutaneous pruritus. Conclusion：Transdermal fentanyl were convenient, effective and with minor averse events in managing cancer pain clinically.