微RNA与胰腺癌研究进展

Research Progress of MicroRNA in Pancreatic Cancer

胰腺癌是恶性程度较高的肿瘤之一,目前早期手术是根治胰腺癌的唯一治疗方法。如何提高胰腺癌高危人群早期筛查确诊率、提高癌变组织药敏性及改善胰腺癌晚期患者生存质量是胰腺癌研究中的重点及难点。微RNA通过特异性识别其靶基因3'端或5'端非翻译区并与之结合的方式调控靶基因的表达,可作为癌基因和抑癌基因在肿瘤的发生、发展、侵袭、转移和耐药等过程中起重要作用,在临床上有望成为诊断、耐药和预后判断的分子标志物。

Pancreatic cancer is one of the most common malignant tumors. Early operation is the only radical treatment of pancreatic cancer. How to improve the early diagnosis rate of high-risk population screening for pancreatic cancer,improve the cancerous tissue drug sensitivity and life quality of patients with advanced pancreatic cancer are the focuses and difficulty in the study of pancreatic cancer. MicroRNA plays an important role as oncogenes and tumor suppressor gene in the process of tumorigenesis,development,invasion,metastasis and drug resistance through regulating the target gene expression by specific recognition of and combination with the target gene 3＇ or 5＇ end non-translation region. MicroRNA is expected to become the molecular markers of the diagnosis,drug resistance and prognosis judgment in clinical.