中医综合干预方案对卒中后轻度认知功能障碍疗效评价

Evaluation of TCM comprehensive intervention on mild post-stroke cognitive impairment

目的:综合评价中医综合干预方案对卒中后轻度认知功能障碍患者的临床疗效。方法:纳入卒中后轻度认知功能障碍患者,随机分为治疗组、对照组,治疗组给予中药(复方苁蓉益智胶囊)+中医特色疗法+非药物干预,对照组给予非药物干预,疗程180d。采用蒙特利尔认知评估量表(MoCA)、日常生活活动能力量表(ADL)及中医核心症状对干预方案进行综合评价。结果:干预180d后,治疗组较对照组MoCA总分显著提高明显(P<0.01);两组ADL总分均较干预前下降(P<0.01,P<0.05);治疗组对"言谈不知首尾,时作时止""转盼遗忘""语后便忘,思量不能""神思不聚""言语懒""兴趣索然""烦躁易怒"等7条中医核心症状有显著改善作用(P<0.01,P<0.05)。结论:中医综合干预方案能够改善卒中后轻度认知功能障碍患者认知功能,提高日常生活能力,改善中医核心症状,具有较好的临床疗效。

Objective： To evaluate the efficacy of TCM comprehensive intervention on the mild post-stroke cognitive impairment. Methods： The cases of patients with mild post-stroke cognitive impairment were randomly divided into intervention group and control group. The intervention group was treated with traditional Chinese medicine（compound Congrong Yizhi Capsule） ＋ TCM featured therapies ＋ non-medicinal intervention, and the control group was treated with non-medicinal intervention, with a 180-day treatment course. The score of Montreal cognitive assessment（MoCA）, activities of daily living（ADL） and the core terminology of TCM were used to evaluate the effect of the intervention. Results： The totle score of MoCA in the intervention group was higher than that in the control group（P〈0.01）. Compared with before the treatment, the totle score of ADL in the two groups after the treatment were improved, with a statistical difference（P〈0.01, P〈0.05）. It also showed that 7 pieces of core symptoms in the intervention group were improved, such as occasional forgetfulness when talk, forgetfulness in the twinkling of an eye, forgetfulness after talk that don＇t memory by thinking, distraction, less communication, loss of interest, and irritability（P〈0.01, P〈0.05）. Conclusion： The TCM comprehensive intervention could improve the mild post-stroke cognitive impairment from the cognitive functions, activities of daily living and the TCM core symptoms. Therefore, it has a good clinical efficacy.