泌尿生殖系感染患者尿液中沙眼衣原体、淋球菌、解脲脲原体感染分析

Analysis on prevalence of Chlamydia trachomatis,Neisseria gonorrhoeae and Ureaplasma urealyticum infections in the patients with urogenital system infection

目的检测泌尿生殖系统感染患者尿液中沙眼衣原体（CT）、淋球菌（NG）、解脲脲原体（UU）感染状况,并进一步了解CT、NG、UU病原体在深圳市的感染情况,为临床诊治提供实验室依据。方法采集疑似泌尿系统感染的609例患者（其中男305例,女304例）尿液,并选取其中108例患者同时采集尿液、分泌物,采用实时荧光聚合酶链反应（PCR）检测CT、NG、UU。结果 CT、NG、UU在分泌物及尿液中的检测结果比较差异无统计学意义（P〉0.05）。单纯感染UU阳性率最高,为42.04%（256/609）;CT＋NG＋UU感染患者感染率为0.33%（2/609）;CT＋UU感染是双重感染中最高,为2.63%（16/609）。男性患者CT、NG、UU感染率分别为：29.18%（89/305）、14.10%（43/305）、52.45%（160/305）;女性患者CT、NG、UU感染率分别是：3.29%（10/304）、2.63%（8/304）、31.58%（96/304）。〈20岁者CT、NG、UU阳性检出率为64.00%,20~29岁者为63.16%,〉29~39岁者为63.34%,〉39岁者为75.00%。结论采用尿液和分泌物检测CT、NG、UU的检出率基本一致;CT、NG、UU的感染率后者明显高于前二者,混合感染以CT＋UU感染率最高;男性患者CT、NG、UU感染率均高于女性。

Objective To detect and analyze the Chlamydia trachomatis（CT）,Neisseria gonorrhoeae（NG）,Ureaplasma urealyticum（UU）infection status of urogenital system and to provide laboratory evidence for clinical diagnosis and treatment.Methods The urine of 609 patients with suspected urinary tract infections（305male cases,304 female cases）were selected as well as secretion of urinary and reproductive system in 108 patients among them.Using real-time fluorescence polymerase chain reaction technique,CT,NG and UU were detected.Results CT,NG and UU between secretions and urine had no significant difference（P〉0.05）.Positive rate of UU in simple urinary track infection was the 42.04%（256/609）,higher than that of CT and NG.The rate of mixed infection of CT,NG and UU was 0.33%（2/609）.The rate of co-infection of CT and NG was up to 2.63%（16/609）,higher than any other kind of co-infection.Rates of CT,NG and UU infection in male patients were 29.18%（89/305）,14.10%（43/305）and 52.45%（160/305）,respectively.And the rates of CT,NG and UU infection in female were 3.29%（10/304）,2.63%（8/304）and 31.58%（96/304）,respectively.In addition,the total infection rate in the patients younger than 20 years old,from 20 to 28years,from 29 to 38years and older than 38 years were 64.00%,63.16%,63.34% and 75.00%,respectively.Conclusion The detection rates in secretions are coincident with that in urine.The infection rate of UU is significantly higher than that of CT and NG.The mixed infection rate of CT and UU is the highest.The infection rates of males are higher than that of females.