血清肿瘤标志物联合检测在原发性肝癌诊断中的临床价值

The clinical value of combined detection of 4 serum tumor markers for the diagnosis of primary liver cancer

目的探讨血清肿瘤标志物,包括α-L岩藻糖苷酶（AFU）、甲胎蛋白（AFP）、癌胚抗原（CEA）、γ-谷氨酰转移酶（GGT）联合检测在原发性肝癌诊断中的临床价值。方法选取2015年1~12月泸州市市妇幼保健院/泸州市第二人民医院收治的80例原发性肝癌患者及80例良性肝病患者,以及同期进行健康体检的100例健康者,均进行血清肿瘤标志物AFU、AFP、CEA、GGT联合检测及对比分析。结果原发性肝癌患者血清肿瘤标志物（AFU、AFP、CEA、GGT）水平显著高于健康对照组和良性肝病组,组间比较差异均有统计学意义（P〈0.05）。4种血清肿瘤标志物联合检测的阳性率显著高于单项检测,而阴性率显著低于单项检测,组间比较差异均有统计学意义（P〈0.05）。结论采用血清肿瘤标志物（AFU、AFP、CEA、GGT）联合检测诊断原发性肝癌,能够提高诊断的阳性率,从而有助于原发性肝癌的早期诊断,对提高患者治疗效果具有重要意义,值得临床推广应用。

Objective To explore the clinical value of combined detection of serum tumor markers includingα-L-fucosidase（AFU）,α-fetoprotein（AFP）,cancer embryo antigen（CEA）and gamma-glutamyl transpeptidase（GGT）for the diagnosis of primary liver cancer.Methods 80 cases of primary liver cancer patients,80 patients with benign liver diseases and 100 cases of healthy subjects were selected from January 2015 to December 2015.All the individuals were measured with serum levels of AFU,AFP,CEA and GGT.And the results of detection were compared and analyzed in different groups.Results The serum levels of the four kinds of tumor markers in patients with primary liver cancer were significantly higher than that in the health control group and benign liver disease group（P〈0.05）.The combined detection had higher positive rate than any single item of the four serum tumor markers,and the differences had statistical significances（P〈0.05）.In addition,the combined detection had the lower negative rate than any single item of the four serum tumor markers,and the differences had statistical significances（P〈0.05）.Conclusion The combined detection of AFU,AFP,CEA,GGT can improve the positive rate of primary liver cancer,which could be helpful for the early diagnosis of primary liver cancer and have great significance to improve the effect of treatment for patients.Combined detection of tumor markers is worthy of clinical popularization and application.