正常人简单与复杂乘法运算的功能磁共振成像研究

Brain Activation in Simple or Complex Multiplication Tasks in Normal Subjects: A Functional Magnetic Resonance Imaging Study

目的探讨正常人完成简单与复杂乘法运算任务时的脑功能激活特征。方法 2010年6月~2012年6月,采用任务态功能磁共振成像（f MRI）,观察13名正常人完成对照任务、视空间记忆、简单（一位数）乘法和复杂（二或三位数）乘法4种任务下激活的脑区。结果相较于对照任务,视空间记忆任务主要激活双侧枕叶、右侧楔前叶、右侧顶上小叶;简单乘法任务主要激活双侧枕中回、左侧顶上小叶、左侧扣带回、左侧额中回以及左侧额下回;复杂乘法任务主要激活右侧顶上小叶、右侧额下回和双侧额中回。结论复杂乘法运算的正确执行依赖于一个右侧顶-额叶网络,该网络支持计算过程空间布局信息的存储。

Objective To explore the characteristics of brain activation when solving simple multiplication and complex multiplication tasks. Methods From June, 2010 to June, 2012, Thirteen normal subjects completed four functional magnetic resonance imaging（f MRI） experiments, including control tasks, visuospatial memory tasks, simple（single-digit） multiplication tasks and complex（multi-digit） multiplication tasks. Results Compared with the control tasks, visuospatial memory tasks activated the bilateral occipital lobe, the right precuneus and superior parietal lobe; simple multiplication tasks activated the bilateral middle occipital gyri, the left superior parietal lobe, the left cingulate gyrus, the left middle frontal gyrus and inferior frontal gyrus; complex multiplication tasks activated the right superior parietal lobe, the right inferior frontal gyrus, and the bilateral middle frontal gyri. Conclusion A right parieto- frontal network is involved in the multi- digit multiplication, which supports the containing of the spatial layout information.