前列地尔治疗突聋的临床疗效观察

Clinical Efficacy of Alprostadil Treatment of Sudden Deafness

目的观察前列地尔治疗突聋的临床疗效。方法选择我科2012年1月至2014年12月期间128例突聋患者为研究对象,将其随机分成两组,每组64例,对照组采用常规治疗方法;试验组在常规治疗基础上加用前列地尔注射液进行治疗。比较两组患者治疗前、后听力、血液流变学指标。结果试验组听力较治疗前提高(P=0.037),血液流变学指标显著改善(P<0.05),差异有统计学意义。结论前列地尔治疗突聋效果显著,能有效缓解症状,提高听力和患者生活质量,改善血液流变学指标,在临床治疗中值得推广应用。

Objective This study aimed to observe the alprostadil treatment of sudden deafness clinical efficacy.Methods The 128 cases of sudden deafness patients in our department from January 2012 to December 2014,were followed up retrospectively.The cases were randomly divided into two groups,each of the 64 patients,the control group received conventional treatment methods and experimental group received conventional treatment based on treatment with alprostadil injection.The hearing,hemorheology in two groups of patients were compared before and after treatment.Results The hearing of the experimental group was improved（P=0.037）,and hemorheology was significantly ameliorated（P〈0.05）.Conclusion The alprostadil treatment of sudden deafness gain significant effect,can effectively relieve symptoms and improve quality of life in patients with hearing and hemorheology improved,which should be widely applied in clinical treatment.