血管性血友病因子在冠心病中的研究进展

vWF research progress in CHD

血管性血友病因子(v WF)是血管内皮细胞活化以及损伤的重要标志物。血液循环中的v WF基本由血管内皮细胞生成,血管内皮细胞发生活化或损伤,血浆v WF水平会明显上升。血管内皮细胞在动脉粥样硬化过程中有着重要作用,v WF在血栓形成过程中有着重要作用,有众多关于v WF水平和动脉粥样硬化及冠心病之间关系的研究,目前认为v WF水平可能反映动脉粥样斑块的程度,也与相关的动脉血栓形成有密切关系。多数研究支持v WF水平和冠心病之间有相关性,高v WF水平是动脉血栓形成的危险因素,监测v WF的水平可以判断高凝状态,评估冠心病的不良事件以及预后,可以对治疗以及药物开发起到帮助作用。

Von Willebrand factor（v WF） is an important biomarker of endothelial cell activation and cell damage. v WF is primaryly synthesized by endothelial cell. The level significantly increases when there are damages of the vascular endothelium cell. Since endothelial cell plays a crucial role in atherosclerosis, v WF has important function on thrombus formation. Numerous scientific studies evaluated the relationship between v WF level, Atherosclerosis and Coronary heart diseases（CHD）. Some authors have noted that high v WF levels are encountered during cardiovascular disorders and artery thrombus formation, it is a high risk factor of CHD. Some studies have revealed related v WF level to different degrees of carotid artery atherosclerotic plaque. Monitoring of v WF level can estimate hyper coagulation state, evaluate the adverse events and prognosis of CHD, and help with the CHD drug development.