转录因子Fos蛋白家族在药物成瘾中的作用

The role of Fos protein family of transcription factors in drug addiction

Fos蛋白家族是一种第三信使,能够调控靶基因的转录过程。Fos蛋白家族中的FosB,c-fos和ΔFosB在药物成瘾中具有重要作用。对Fos蛋白家族的研究将指引对药物成瘾过程神经机制的理解,并为开发低耐受性、低依赖性镇痛药物和药物依赖的防治以及解决戒毒后的"复吸"等问题奠定基础。

The Fos family is a third messenger,which can regulate the transcription of target genes. FosB,c-fos and FosB in Fos protein family play an important role in drug addiction. Further study on Fos family will lead to expand the understanding of the neural mechanisms underlying opioid addiction,and provide an effective way for the development of low tolerance,low dependence of pain medicine as well as for the treatment of opioid addiction and relapse.