脉冲式低剂量率放射治疗技术对放疗后复发肿瘤再程放疗的临床观察

Clinical observation of reirradiation by pulsed low dose rate RT for recurrent cancer patients

目的观察脉冲式低剂量率放射治疗对放疗后复发肿瘤再程放疗的效果。方法入组40例经放射治疗后出现肿瘤复发的患者,随机分组,进行三维适形放疗(3DCRT)和脉冲式低剂量率放疗,观察脉冲式低剂量率放疗对复发肿瘤的再程放疗的超敏反应,观察实验组的生存期及正常组织的耐受情况。结果复发肿瘤的再程放疗应用脉冲式低剂量率技术的有效率80%,1年、2年生存率分别为85%、25%,高于三维适型治疗组,并且患者耐受性好,对正常组织更好的保护。结论脉冲式低剂量率放射对复发肿瘤的再程放疗疗效肯定,疾病缓解率高,患者耐性好,生存时间延长。

Objective A consensus standard of care has not been established for treating recurrent cancer patients who have previously undergone radiation. Several studies have shown that pulsed low dose rate（ PLDR） radiotherapy has the potential to reduce normal tissue toxicities while still providing significant tumor control for recurrent cancers. Methods Forty cases of recurrent cancer patients after radiotherapy were included in this study,treated by 3DCRT and PLDR. Observed allergic reactions to impulse type low dose rate radiation therapy,and observed the survival period of patients and normal tissue tolerance. Results The effective rate of recurrent cancer patients is 80% by using pulsed low dose rate radiation technology. The survival rate was higher compare with treated by 3DCRT,1 year of survival rate was 85% and 2 years of survival rate was 25%. The patients present well tolerance,and this method was proved to have better protective effect on normal tissues.Conclusions For recurrent cancer patients pulsed low dose rate（ PLDR） radiotherapy has better efficacy,higher response rate and could prolong survival time.