期刊文献+

DNMT2在脑胶质瘤的表达

下载PDF
导出
摘要 目的探讨脑胶质瘤与DNMT2表达之间的关系。方法采用免疫组织化学方法检测不同级别脑胶质瘤DNMT2表达水平变化。结果与分化程度为Ⅰ级脑胶质瘤样本比较,Ⅱ级、Ⅲ级、Ⅳ级的脑胶质瘤DNMT2的表达上调(P<0.05);与分化程度为Ⅱ级脑胶质瘤样本比较,Ⅲ级、Ⅳ级的脑胶质瘤DNMT2的表达上调(P<0.05);但是Ⅲ级和Ⅳ级之间的脑胶质瘤DNMT2的表达无统计学差异(P>0.05)。结论 DNMT2与脑胶质瘤的恶性程度相关,可能成为脑胶质瘤的客观诊断标准。
出处 《齐齐哈尔医学院学报》 2016年第9期1217-1218,共2页 Journal of Qiqihar Medical University
  • 相关文献

参考文献8

  • 1Sontheimer H. Brain cancer:Tumour ceils on neighbourhood watch [J]. Nature,2015,528:49-50.
  • 2Kanu OO, Mehta A, Di C, et al. Glioblastoma multiforme : a review of therapeutic targets [ J ]. Expert opinion on therapeutic targets,2009, 13:701-718.
  • 3Noushmehr H, Weisenberger DJ, Diefes K, et al. Identification of a CpG island methylator pHenotype that defines a distinct subgroup of glioma[ J]. Cancer cell,2010,17:510-522.
  • 4Feng J, Zhou Y, Campbell SL, et al, Dnmtl and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons[ J]. Nature neurescience ,2010,13:423-430.
  • 5Schaefer M, Lyko F. Solving the Dnmt2 enigma[ J]. Chromosoma, 2010,119:35-40.
  • 6Goll MG, Kirpekar F, Maggert KA, et al. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science, 2006; 311: 395-398.
  • 7Schaefer M, Pollex T, Hanna K, et al. RNA methylation by Dnmt2 protects transfer RNAs against stress - induced cleavage [ J ]. Genes & development ,2010,24 : 1590-1595.
  • 8Muller S, Windhof IM, Maximov V, et al. Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2 - homologue ( DnmA ) [ J ]. Nucleic acids research,2013,41:8615-8627.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部