期刊文献+

Ki-67在犬乳腺肿瘤的表达与分析

下载PDF
导出
摘要 本试验通过免疫组化的方法,检测了从中国农业大学教学动物医院收集到的6个正常乳腺组织和135例乳腺肿瘤组织(良性30例,恶性105例)Ki-67的表达率。结果犬乳腺肿瘤组织中的Ki-67蛋白表达率明显高于正常乳腺组织(P<0.05);犬恶性肿瘤组织中的Ki-67蛋白表达率明显高于良性肿瘤(P<0.05)。表明Ki-67在恶性肿瘤里高表达,可以作为犬乳腺肿瘤疾病诊断的指标。
出处 《中国兽医杂志》 CAS 北大核心 2016年第5期38-40,I0003,共4页 Chinese Journal of Veterinary Medicine
基金 国家自然科学基金(31572578 31372489)
  • 相关文献

参考文献10

  • 1Shafiee R,Javanbakht J,Atyabi,N,et al.Diagnosis,classifica tion and grading of canine mammary tumours as a model to stud human breast cancer:an Clinico-Cytohistopathological study with environmental factors influencing public health and medicine[J].Cancer Cell Int,2013.13:79.
  • 2Brown D C,Gatter K C.Monoclonal antibody Ki-67:its use in histopathology[J].Histopathology,1990,17(6):489-503.
  • 3何振宇,李彪,胡英,管迅行.Ki67在乳腺癌组织中的表达及临床病理分析[J].中国初级卫生保健,2005,19(12):94-95. 被引量:16
  • 4Ng I O,Na J,Lai E C,et al.Ki-67 antigen expression in hepatocellular carcinoma using monoclonal antibody MIB1.A comparison with proliferating cell nuclear antigen[J].Am J Clin Pathol,1995,104:313-318.
  • 5Garzetti G G,Ciavattini A,Goteri G,et al.Ki67 antigen immunostaining(MIB 1 monoclonal antibody)in serous ovarian tumors:index of proliferative activity with prognostic significance[J].Gynecol Oncol,1995.56:169-174.
  • 6王晓琴,戴穹,杨志惠.bcl-2、Ki-67和bax蛋白在宫颈上皮内瘤变和宫颈癌中的表达及临床意义[J].中国医疗前沿(学术版),2008,3(1):27-28. 被引量:9
  • 7宋作庆,徐萧洪,韦森,陈军,刘懿,李昕,赵洪林,邱小明,周乃康.肝素酶及Ki-67在非小细胞肺癌中的表达及临床意义[J].中国肺癌杂志,2009,12(7):785-788. 被引量:13
  • 8Huanan W,Xu Y,Yipeng J,et al.Expression and significance of CHIP in canine mammary gland tumors[J].J Vet Med Sci,2015,77:1465-1471.
  • 9Mac Callum D E,Hall P A.The location of p Ki67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle[J].J Pathol,2000,190:537-544.
  • 10Yerushalmi R,Woods R,Ravdin P M,et al.Ki67 in breast cancer:prognostic and predictive potential[J].Lancet Oncol,2010.11:174-183.

二级参考文献17

  • 1宋作庆,徐萧洪,韦森,陈军,周乃康.肝素酶在非小细胞肺癌中的表达及其临床意义[J].中国肺癌杂志,2008,11(6):798-801. 被引量:6
  • 2陈香丽,张王刚,陈小燕,孙忠民,刘苏虎.S100A4蛋白在非小细胞肺癌中的表达与侵袭和转移的关系[J].癌症,2006,25(9):1134-1137. 被引量:18
  • 3邓志敏,金黎,陈晶儿,杨琳,郝艳华,吴双珍.bcl-2和bax蛋白在宫颈上皮内瘤样变和宫颈癌中的表达及意义[J].广东医学,2007,28(4):549-550. 被引量:10
  • 4张亚静,拉莱.苏祖克.p16、Ki-67在子宫颈上皮内瘤变及子宫颈鳞癌中的表达及意义[J].新疆医科大学学报,2007,30(4):372-374. 被引量:8
  • 5Rayband-Diogene H,Fortin A,Moreney R,et al.Markers of Radioresistance in squamous cell carcinomas of the Head and neck:A Clinicopathologic and Immunohistochemical study [J].J clin Oncology,1997,15(3):1030-1038.
  • 6Tan PH,Bay BH,YipG,et al.Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death [J].Mod Pathol,2005,18(3):374-381.
  • 7Gerdes J,Lemke H,Baisch H,et al.Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoelonal antibody Ki67 [J].J Immunol,1984,133(13):1710-1715.
  • 8Ramires M,David L,Leitao D,et al.Ki67 labelling index in gastric carcinomas [J].J Pathology,1997,182(1):62-67.
  • 9Liu SC,Edward Rs,Margic LC,et al.Markers of cell proliferation in normal epithelia and dysplastic leakoplakias of the oral cavity[J].Cancer Epidemind Biom Prevention,1998,7(5):598-603.
  • 10Tut VM,Braithwaite AL,Angus B,et al.Cyclin D expression in transitional cell carlinoma of the bladder;correlation with p53,wafl,PRb and Ki67 [J].Br J Cancer,2001,84(2):270-275.

共引文献32

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部