复方双氯芬酸钠注射液的解热镇痛药效试验

The antipyretic analgesic action of the Compound diclofenac sodium injection

为了考察复方双氯芬酸钠注射液的解热镇痛效果,方法一:选取基础体温正常的健康新西兰兔,除空白对照组外,其余各组均静脉注射60 EU/kg体重的细菌内毒素进行致热,致热成功后开始给药,观察药物对发热新西兰兔的解热效果;方法二:选取正常小鼠,各组于给药后30 min腹腔注射0.5%的冰醋酸溶液0.2 m L,注射后立即观察1 5min内小鼠的扭体反应次数,计算扭体反应的抑制率。结果表明:复方双氯芬酸钠注射液起效快,作用时间长,对细菌内毒素所致新西兰兔发热的解热效果和对醋酸所致小鼠的镇痛效果,均优于对乙酰氨基酚注射液。

Objective：To investigate the compound diclofenac sodium injection of antipyretic analgesic effect.Method one：Select the healthy New Zealand rabbits,and in addition to the blank control group,the rest of the groups were injected intravenously with 60 eu/kg of bacterial endotoxin. Then observe the antipyretic effect of drug on the hot New Zealand rabbit. Method 2：Select normal mice.For 30 min after celiac injection of 0.2 m L of 0.5% glacial acetic acid solution then we observed the effects within 15 min after injection in mice body torsion reaction times immediately,and calculated the inhibition rate of body torsion reaction.The results showed that the compound diclofenac sodium injection worked fast and maintained a long time.The antipyretic analgesic effect is better than the acetaminophen injection.