肝细胞癌中上皮间质转化及其相关信号通路的研究进展

Epithelial-mesenchymal transition and related signaling pathways in hepatocellular carcinoma

肝细胞癌(hepatocellular carcinoma,HCC)是一种最常见的肝癌,世界上癌症相关死亡的第3大常见原因.尽管各种治疗手段已经用于处理该致死性疾病,HCC患者的预后仍然很不理想,术后5年生存率大约为30%.术后复发转移是HCC患者预后不良的主要因素,这一过程被认为依赖于非运动性上皮肿瘤细胞获得间质细胞特征,称为上皮间质转化(epithelial-mesenchymal transition,EMT),E M T已经被认为是导致H C C侵袭转移的主要因素之一.值得注意的是,越来越多的证据表明多个信号通路参与调节HCC的EMT进展,本文将对近年来HCC中EMT及其相关信号通路的研究进展进行简要综述.

Hepatocellular carcinoma（HCC） is one of themost common forms of liver cancer and the third leading cause of cancer-related mortality in the world. Although numerous therapeutic strategies have been employed to treat this fatal disease, the prognosis of HCC patients remains dismal with a low 5-year survival rate of approximately 30%. Postoperative recurrence and metastasis of HCC are the leading cause of poor prognosis. Metastasis has been thought to rely on non-motile epithelial tumor cells acquiring characteristics of mesenchymal cells, which are more migratory. This change is known as the epithelial-to-mesenchymal transition（EMT）. EMT has been considered one of the main reasons for the invasion and metastasis of HCC. Notably, increasing evidence indicates that several signaling pathways participate in the regulation of EMT in HCC. In the current review, we will discuss the current progress in research of EMT and its related signaling pathways in HCC.most common forms of liver cancer and the third leading cause of cancer-related mortality in the world.Although numerous therapeutic strategies have been employed to treat this fatal disease,the prognosis of HCC patients remains dismal with a low 5-year survival rate of approximately 30%.Postoperative recurrence and metastasis of HCC are the leading cause of poor prognosis.Metastasis has been thought to rely on non-motile epithelial tumor cells acquiring characteristics of mesenchymal cells,which are more migratory.This change is known as the epithelial-to-mesenchymal transition（EMT）.EMT has been considered one of the main reasons for the invasion and metastasis of HCC.Notably,increasing evidence indicates that several signaling pathways participate in the regulation of EMT in HCC.In the current review,we will discuss the current progress in research of EMT and its related signaling pathways in HCC.