大肠癌术后化疗联合加味升阳益胃汤的临床疗效

Clinical effects of Jiawei Shengyang Yiwei soup combined with postoperative chemotherapy for colorectal cancer

目的:探讨大肠癌术后化疗联合加味升阳益胃汤的临床疗效.方法:选取武汉市第五医院2013-10/2014-10诊治的大肠癌患者98例,均行手术切除术治疗.采用随机数字表法分为两组,对照组患者49例实施术后化疗,观察组患者49例实施术后化疗联合加味升阳益胃汤治疗,比较两组患者的临床疗效.结果:两组患者治疗后癌胚抗原、白细胞计数、中性粒细胞、C反应蛋白较治疗前降低(P<0.05).两组患者治疗后生存质量(生理状况、社会家庭状况、情感状况、功能状况、公共板块、附加关注、总分)评分较治疗前增加(P<0.05).观察组患者治疗后癌胚抗原、白细胞计数、中性粒细胞、C反应蛋白低于对照组(P<0.05).观察者患者治疗后生存质量(生理状况、社会家庭状况、情感状况、功能状况、公共板块、附加关注、总分)评分高于对照组(P<0.05).观察组患者肠鸣音恢复时间、术后排气时间、术后排便时间早于对照组(P<0.05).观察组患者术后住院时间少于对照组(P<0.05).观察组患者不良反应发生率低于对照组(P<0.05).结论:大肠癌术后化疗联合加味升阳益胃汤的疗效显著,可减轻炎症反应,提高生存质量.

AIM：To evaluate the clinical effects of Jiawei Shengyang Yiwei soup combined with postoperative chemotherapy for colorectal cancer.METHODS：Ninety-eight colorectal cancer patients surgically treated from October 2013 to October 2014 at the Fifth Hospital of Wuhan were chosen and randomly divided into either a control group or an observation group,with 49 patients in each group.The control group received postoperative chemotherapy alone,and the observation group received Jiawei Shengyang Yiwei soup combined with postoperative chemotherapy.Clinical effects were compared between the two groups.RESULTS：After treatment,carcinoembryonic antigen,white blood cell count,neutrophil count,and C reactive protein significantly decreased（P〈0.05）,while quality of life（physiological status,social and family status,emotional status,functional status,public sector,additional attention,and total score）scores significantly increased in the two groups（P〈0.05）.Carcinoembryonic antigen,white blood cell count,neutrophil count,and C reactive protein in the observation group were significantly lower than those of the control group（P〈0.05）,while quality of life（physiological status,social and family status,emotional status,functional status,public sector,additional attention,total score） scores in the observation group were significantly higher（P〈0.05）.Times to bowel sound,postoperative exhaust,and postoperative defecation were shorter in the observation group than in the control group（P〈0.05）.Postoperative hospitalization time in the observation group was shorter than that of control group（P〈0.05）.Incidence of adverse reactions in the observation group was lower than that of the control group（P〈0.05）.CONCLUSION：Jawei Shengyang Yiwei soup combined with postoperative chemotherapy for colorectal cancer has significant clinical effects,and can relieve inflammatory reaction and improve quality of life.