以腰椎转移症状为首发表现的食管神经内分泌癌1例

One case of neuroendocrine carcinoma of the esophagus with symptoms of lumbar spinal metastasis as initial manifestation

神经内分泌癌是发生自神经内分泌细胞的一类恶性肿瘤.本文报道以腰椎转移症状为首发表现的食管神经内分泌癌1例,患者,男性,52岁,以腹痛、腰痛、消瘦半月入院.胃镜及病理:食管癌.免疫组织化学:食管小细胞神经内分泌癌.肝脏增强MRI:肝脏多发转移瘤.胸、腰椎MRI:胸腰骶椎体骨髓浸润.本例患者应用依托泊苷等化疗3疗程,症状有所好转.

Neuroendocrine carcinoma is a malignant tumor that arises from cells of the endocrine and nervous systems.Here we report a case of neuroendocrine carcinoma of the esophagus with symptoms of lumbar spinal metastasis as initial manifestation.A 52-year-old male patient presented with abdominal pain,low back pain,and weight loss for half a month.Gastroscopic and pathological examinations suggested a diagnosis of esophageal carcinoma.Immunohistochemical staining revealed esophageal small cell neuroendocrine carcinoma.Enhanced MRI showed multiple metastatic lesions in the liver,as well as thoracolumbar and lumbosacral vertebral bone marrow infiltration.After three cycles of etoposide chemotherapy,the symptoms of the patient improved.