IVIM序列诊断前列腺癌和前列腺增生价值的研究

Value of IVIM sequence in diagnosis of prostate cancer and benign prostatic hyperplasia

目的探讨体素内不相干运动弥散加权(IVIM)序列各参数鉴别诊断前列腺癌和前列腺增生的价值。方法病理证实的前列腺癌57例和前列腺增生45例患者分别行磁共振IVIM序列和DWI序列检查,比较前列腺癌和前列腺增生患者的的ADC值、纯弥散系数(Dslow)、伪弥散系数(Dfast)以及灌注分数(f)值的差异。前列腺癌和前列腺增生各参数的数据建立ROC曲线,分析ROC曲线下的面积(AUC),比较各参数的诊断效能。结果前列腺癌的ADC值、Dslow值明显低于前列腺增生,f值高于前列腺增生,以P≤0. 05为差异有统计学意义,Dfast值差异无统计学意义。ROC曲线下方Dslow的AUC最大,Dslow的诊断效能最高。结论 ADC值、Dslow、f都可以鉴别诊断前列腺癌和前列腺增生,但是Dslow具有最高的诊断效能。

Objective To investigate value of the parameters of intravoxel incoherent motion ( IVIM) sequence in the differential diagnosis of prostate cancer and prostatic hyperplasia. Methods Fifty cases of prostate cancer and 45 cases of benign prostatic hyperplasia were examined by magnetic resonance IVIM sequence and DWI sequence,and the ADC value,the pure diffusion coefficient ( Dslow) ,the pseudo diffusion coefficient ( Dfast) and perfusion fraction ( f) value of the patients with prostate cancer and prostatic hyperplasia was compared. The parameters of prostate cancer and benign prostatic hyperplasia were established,and the ROC curve was established. The area under the ROC curve ( AUC) was analyzed,and the diagnostic efficiency of each parameter was compared. Results The value of ADC and Dslow of prostate cancer was significantly lower than that of benign prostatic hyperplasia,and the value of F was higher than that of benign prostatic hyperplasia. The difference of P≤0. 05 was statistically significant,and the difference of Dfast value was not statistically significant. The AUC of the Dslow below the ROC curve was the largest and the diagnostic efficiency of Dslow was the highest. Conclusion ADC,Dslow and F can differentiate prostate cancer from benign prostatic hyperplasia,but Dslow has the highest diagnostic efficiency.