有序介孔硅微球吸附钌联吡啶修饰碳糊电极电致化学发光测定阿替洛尔

Sensitive determination of atenolol based on electrogenerated chemiluminescence of tris(2,2'- bipyridyl) ruthenium(Ⅱ) immobilized inmesoporous silica modified carbon paste electrode

合成了一种有机-无机介孔硅微球材料,以此材料吸附钌联吡啶制备了修饰碳糊电极,并以此电极为工作电极,以Ag/Ag Cl电极为参比电极,铂丝电极为辅助电极,考察了以三丙胺作为Ru（bpy）3^2＋共反应剂的电致化学发光性能。基于阿替洛尔对钌联吡啶电致化学发光增强作用,建立了药片及尿样中阿替洛尔含量测定的新方法。该方法对阿替洛尔检出限为0.5μg/m L,线性范围是5~40μg/m L.

The mesoporous organic- inorganic hybrid microspheres was sythesized and employed to immobilize the tris（ 2,2＇-bipyridyl） ruthenium（ II） to modify carbon paste electrode. The modified carbon paste electrode as the working electrode,Ag /Ag Cl electrode as the reference electrode,platinum electrode as auxiliary electrode,the electrochemical and ECL behaviors of Ru（ bpy）3^2 ＋immobilized in ordered mesoporous silica modified carbon paste electrode was investigated. The modified electrode showed an electrocatalytic response to the oxidation of atenolol,producing a sensitive ECL signal. Under the optimum conditions,the ECL sensor showed a linear response to atenolol in the range of 5 - 40μg / m L with a detection limit of 0. 5μg /m L. The method was successfully applied for the determination of atenolol in pharmaceutical samples and urine samples.