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胰岛素抵抗与炎症因子 被引量:1

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摘要 近年来,许多研究发现在胰岛素抵抗人群中IL-6、IL-8、TNF-α、CRP、PAI-1等血浆浓度明显升高。这些炎症因子可通过胰岛素受体酪氨酸磷酸化、抑制胰岛素受体信号传导,降低葡萄糖转运体mRNA的表达水平,影响胰岛素作用及葡萄糖代谢,且通过瘦素、脂联素等细胞因子的相互作用,参与胰岛素抵抗的发生和发展。
作者 金仲品
机构地区 滨州职业学院
出处 《滨州职业学院学报》 2005年第3期71-74,共4页 Journal of Binzhou Polytechnic
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