MiR-21对脑胶质瘤的诊断及预后评估价值的Meta分析

Value of micro RNA-21 in the diagnosis and prognosis for glioma: a meta analysis

【目的】本研究利用Meta分析的方法对mi R-21在脑胶质瘤患者诊断及预后评估中的价值进行系统评价。【方法】按照检索式检索Pub Med、Web of science、中国期刊全文数据库收集涉及mi R-21与脑胶质瘤患者诊断及预后相关的临床研究,按照文献纳入及排除标准筛选文献,评价纳入文献质量,最终提取数据资料,应用Stata13.1和Metadisc1.4软件进行Meta分析。【结果】共纳入文献9篇,其中诊断研究4篇,预后研究4篇,另有1篇文章既涉及诊断研究也涉及预后研究。共计1 038例研究对象,其中脑胶质瘤病例数为910例。mi R-21诊断脑胶质瘤的合并灵敏度为0.82（95%CI：0.73~0.88）,合并特异度为0.93（95%CI：0.85~0.97）;脑胶质瘤组织中高mi R-21表达影响患者总生存时间的合并风险比为1.74（95%CI：1.47~2.07,P〈0.05）。【结论】检测mi R-21对于脑胶质瘤病人诊断及评估预后具有较大临床价值。

【Objective】Many studies indicated that micro RNA-21（mi R-21） might be closely related to the diagnosis and prognosis for glioma. However, the conclusions were not consistent. This study aimed to systematically evaluate mi R- 21 in the diagnosis and prognosis for glioma with meta analysis.【Methods】According to the inclusion and exclusion criteria, articles related to mi R-21 and the diagnosis and prognosis for glioma were selected from medical electronic database, including Pub Med, Web of science and CNKI.The quality of inclusive references and final picked data were valued. Meta-analysis was performed with Stata 13.1 and Metadisc 1.4.【Results】A total of 9 references were selected, including 4 studies of diagnosis, 4 studies of prognosis and 1 study of both. There were1 038 cases, including 910 glioma patients. The sensitivity and specificity of mi R-21 in diagnosing glioma were 0.82（95%CI： 0.73~0.88）and 0.93（95% CI： 0.85~0.97） respectively.Combined hazard ratio of overall survival time influenced by high mi R- 21 expression in glioma tissues was 1.74（95% CI： 1.47~2.07,P〈0.05）.【Conclusion】The mi R- 21 detection may be of great clinical value in the diagnosis and prognosis for glioma.